PMID- 25466512
OWN - NLM
STAT- MEDLINE
DCOM- 20150729
LR  - 20181202
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 60
IP  - 2
DP  - 2015 Mar-Apr
TI  - Correlations between serum intact parathyroid hormone (PTH) and 
      N-terminal-probrain natriuretic peptide levels in elderly patients with chronic 
      heart failure (CHF).
PG  - 359-65
LID - S0167-4943(14)00206-4 [pii]
LID - 10.1016/j.archger.2014.11.005 [doi]
AB  - OBJECTIVES: The aim of this study was to investigate the association between PTH 
      and Nt-proBNP in elderly patients with CHF in an attempt to gain insights into 
      the role of PTH in a community-based cohort of elderly patients with CHF. 
      METHODS: A total of 182 consecutive CHF patients with follow-up for mortality 
      after 3 years were prospectively studied. Serum levels of intact PTH, Nt-proBNP 
      and biochemical parameters were examined. The enrolled patients were divided into 
      groups by the levels of PTH and New York Heart Association (NYHA) functional 
      classes. RESULTS: A total of 66 (36%) patients had PTH values above the upper 
      limit of the normal range. Serum creatinine (p=0.001), estimated glomerular 
      filtration rate (eGFR) (p=0.001), Nt-proBNP (p<0.001), serum calcium (p=0.030), 
      heart rate (p=0.002) showed statistical significance in different stages of PTH. 
      The mean PTH and Nt-proBNP levels increased as the NYHA functional class 
      increased. The optimal cut-off value of PTH to predict CHF-related death was 
      48.98 pg/ml, with 57.14% sensitivity and 86.24% specificity. The best cut-off 
      point of Nt-proBNP was 480 ng/ml with 76.47% sensitivity and 80.48% specificity. 
      Over a mean follow-up of 3 years, Kaplan-Meier survival curves demonstrate that 
      patients with higher levels of intact PTH had lower survival time, with a hazard 
      ratio of 2.5 (95% CI 1.5-3.9). CONCLUSIONS: The study has shown that serum intact 
      PTH level obtained in the elderly patients with CHF is a novel biomarker 
      associated with Nt-proBNP and could provide supplementary information for the 
      diagnosis and prognostic prediction of CHF, especially when it is used in 
      combination with Nt-proBNP.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhang, Shuang
AU  - Zhang S
AD  - Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200092, PR China.
FAU - Hu, Yan
AU  - Hu Y
AD  - Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200092, PR China.
FAU - Zhou, Lu
AU  - Zhou L
AD  - Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200092, PR China.
FAU - Chen, Xiaojing
AU  - Chen X
AD  - Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200092, PR China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200092, PR China.
FAU - Wu, Jiayu
AU  - Wu J
AD  - Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200092, PR China.
FAU - He, Huimin
AU  - He H
AD  - Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200092, PR China.
FAU - Gao, Yanhong
AU  - Gao Y
AD  - Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200092, PR China. Electronic address: yhgao2010@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141125
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Biomarkers)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - AYI8EX34EU (Creatinine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Calcium/blood
MH  - China/epidemiology
MH  - Creatinine/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Heart Failure/*blood/*mortality
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Parathyroid Hormone/*blood
MH  - Peptide Fragments/*blood
OTO - NOTNLM
OT  - Chronic heart failure
OT  - Elderly people
OT  - N-terminal-probrain natriuretic peptide
OT  - Parathyroid hormone
EDAT- 2014/12/04 06:00
MHDA- 2015/07/30 06:00
CRDT- 2014/12/04 06:00
PHST- 2014/08/17 00:00 [received]
PHST- 2014/11/16 00:00 [revised]
PHST- 2014/11/18 00:00 [accepted]
PHST- 2014/12/04 06:00 [entrez]
PHST- 2014/12/04 06:00 [pubmed]
PHST- 2015/07/30 06:00 [medline]
AID - S0167-4943(14)00206-4 [pii]
AID - 10.1016/j.archger.2014.11.005 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2015 Mar-Apr;60(2):359-65. doi: 
      10.1016/j.archger.2014.11.005. Epub 2014 Nov 25.