PMID- 25466574
OWN - NLM
STAT- MEDLINE
DCOM- 20151022
LR  - 20151119
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 202
IP  - 3
DP  - 2014 Dec
TI  - Assessment of oxidative stress biomarkers in exhaled breath condensate and blood 
      of dairy heifer calves from birth to weaning.
PG  - 583-7
LID - S1090-0233(14)00438-9 [pii]
LID - 10.1016/j.tvjl.2014.10.025 [doi]
AB  - The balance between oxidants and antioxidants may be impaired in neonatal calves 
      but only limited information is available on physiological changes in oxidative 
      biomarkers in healthy calves. The aim of this study was to measure biomarkers of 
      oxidative stress (OS) in calves from birth to weaning. Eighteen, healthy, female 
      Holstein-Friesian calves were used in the study. Blood and exhaled breath 
      condensate (EBC) samples were taken on the day of birth (Week 0) and then at 
      Weeks 6, 12 and 18. Reactive oxygen metabolites (ROMs) and biological antioxidant 
      potential (BAP) were determined on fresh blood and the degree of OS was expressed 
      as an oxidative stress index (OSI), where OSI = ROMs/BAP x 100. Plasma 
      concentrations of antioxidant barrier (OXY), thiol antioxidant barrier (SH), 
      advanced oxidation protein products (AOPP), albumin, and non-esterified fatty 
      acids (NEFA) were also measured, as was hydrogen peroxide (H2O2) concentration in 
      EBC. Plasma concentrations of ROMs were relatively stable during the trial; AOPP 
      concentration progressively decreased reaching its lowest values on Week 18. 
      Albumin, SH and OXY concentrations progressively increased from birth to weaning. 
      Concentrations of NEFA in plasma and H2O2 in EBC were relatively stable but 
      peaked in Week 18. The results indicate that antioxidative defence not only 
      increases with time in the plasma of new-born calves but also that it is related 
      to protein oxidation processes. Furthermore, the data support the use EBC H2O2 as 
      a novel biomarker to assess respiratory OS in calves.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Ranade, Rujuta
AU  - Ranade R
AD  - Faculty of Veterinary Science, The University of Sydney, Sydney, NSW, Australia.
FAU - Talukder, Saranika
AU  - Talukder S
AD  - Faculty of Veterinary Science, The University of Sydney, Sydney, NSW, Australia.
FAU - Muscatello, Gary
AU  - Muscatello G
AD  - Faculty of Veterinary Science, The University of Sydney, Sydney, NSW, Australia.
FAU - Celi, Pietro
AU  - Celi P
AD  - Faculty of Veterinary Science, The University of Sydney, Sydney, NSW, Australia. 
      Electronic address: pietro.celi@sydney.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141023
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Blood Chemical Analysis/veterinary
MH  - Breath Tests
MH  - Cattle/*metabolism
MH  - Female
MH  - *Oxidative Stress
OTO - NOTNLM
OT  - Calves
OT  - Exhaled breath condensate
OT  - Oxidative stress
OT  - Weaning
EDAT- 2014/12/04 06:00
MHDA- 2015/10/23 06:00
CRDT- 2014/12/04 06:00
PHST- 2014/05/21 00:00 [received]
PHST- 2014/10/12 00:00 [revised]
PHST- 2014/10/17 00:00 [accepted]
PHST- 2014/12/04 06:00 [entrez]
PHST- 2014/12/04 06:00 [pubmed]
PHST- 2015/10/23 06:00 [medline]
AID - S1090-0233(14)00438-9 [pii]
AID - 10.1016/j.tvjl.2014.10.025 [doi]
PST - ppublish
SO  - Vet J. 2014 Dec;202(3):583-7. doi: 10.1016/j.tvjl.2014.10.025. Epub 2014 Oct 23.