PMID- 25467023
OWN - NLM
STAT- MEDLINE
DCOM- 20150601
LR  - 20181202
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 158
DP  - 2014
TI  - [Determination of blood levels for oral anticancer drugs].
PG  - A7884
AB  - Oral tyrosine kinase inhibitors and mammalian target of rapamycin (mTOR) 
      inhibitors are indicated in several types of cancer. They are usually 
      administered at a fixed dose. In recent years, observational studies have 
      reported on the wide variability in exposure to these new drugs, and the 
      relationship between clinical response (efficacy and toxicity) and target plasma 
      concentrations. Additionally, we are gaining insight into different food and drug 
      interactions with these new drugs. On the basis of current drug monitoring, 
      advice can be given on individual dosing of pazopanib in metastatic renal cell 
      cancer (mRCC), sunitinib in mRCC and gastrointestinal stromal tumor (GIST), and 
      imatinib in GIST.
FAU - van Erp, Nielka P
AU  - van Erp NP
AD  - Radboudumc, Nijmegen.
FAU - van der Graaf, Winette T A
AU  - van der Graaf WT
LA  - dut
PT  - Journal Article
TT  - Bloedspiegelbepaling van orale doelgerichte antikankermedicatie.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Protein Kinase Inhibitors)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Administration, Oral
MH  - Antineoplastic Agents/adverse effects/*blood/pharmacokinetics/therapeutic use
MH  - Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse 
      effects/pharmacokinetics
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Humans
MH  - Neoplasms/*blood/*drug therapy
MH  - Protein Kinase Inhibitors/adverse effects/*blood/pharmacokinetics/therapeutic use
MH  - Sirolimus/adverse effects/blood/pharmacokinetics/therapeutic use
MH  - Treatment Outcome
EDAT- 2014/12/04 06:00
MHDA- 2015/06/02 06:00
CRDT- 2014/12/04 06:00
PHST- 2014/12/04 06:00 [entrez]
PHST- 2014/12/04 06:00 [pubmed]
PHST- 2015/06/02 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2014;158:A7884.