PMID- 25467705
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20220409
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 225
IP  - 1-2
DP  - 2015 Jan 30
TI  - Pilot study of cognitive remediation therapy on cognition in young people at 
      clinical high risk of psychosis.
PG  - 93-98
LID - S0165-1781(14)00847-6 [pii]
LID - 10.1016/j.psychres.2014.10.021 [doi]
AB  - Individuals at clinical high risk (CHR) of psychosis evidence cognitive deficits. 
      Given suggestions that deficits in cognition are related to poor functional 
      outcome, cognition is a good treatment target. The aim of this study was to test 
      the efficacy of cognitive remediation therapy (CRT) in improving cognition of CHR 
      individuals. Participants were tested at baseline, immediately following CRT and 
      9 months post-baseline. The mixed effects modelling demonstrated no differences 
      in cognition between the experimental group and the control group at any time 
      point. For the experimental group, however, there was a trend towards improvement 
      in speed of processing between baseline and 9-month follow-up (t(29)=-2.91, 
      P=0.06) and at post-CRT compared to 9-month follow-up (t(29)=-2.99, P<0.05). In 
      the control group, significant improvements in working memory were observed 
      between post-CRT and 9-month follow-up (t(29)=-3.06, P<0.05). Despite significant 
      improvements in social functioning in the intervention group between baseline and 
      9-month follow-up (t(28)=-3.26, P<0.05), these improvements were not correlated 
      with cognition. There were trends towards improvement and no trends of decline in 
      the two groups. While CRT may be valuable for individuals at CHR, the type of 
      intervention employed needs to be carefully considered.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Piskulic, Danijela
AU  - Piskulic D
AD  - Hotchkiss Brain Institute, Department of Psychiatry, Faculty of Medicine, 
      University of Calgary, Calgary, Canada; Orygen, The National Centre of Excellence 
      in Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia. 
      Electronic address: danijela.piskulic@unimelb.edu.au.
FAU - Barbato, Mariapaola
AU  - Barbato M
AD  - Hotchkiss Brain Institute, Department of Psychiatry, Faculty of Medicine, 
      University of Calgary, Calgary, Canada; Mathison Centre for Mental Health 
      Research & Education, Calgary, Alberta, Canada.
FAU - Liu, Lu
AU  - Liu L
AD  - Hotchkiss Brain Institute, Department of Psychiatry, Faculty of Medicine, 
      University of Calgary, Calgary, Canada; Mathison Centre for Mental Health 
      Research & Education, Calgary, Alberta, Canada.
FAU - Addington, Jean
AU  - Addington J
AD  - Hotchkiss Brain Institute, Department of Psychiatry, Faculty of Medicine, 
      University of Calgary, Calgary, Canada; Mathison Centre for Mental Health 
      Research & Education, Calgary, Alberta, Canada.
LA  - eng
GR  - U01MH08984/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141104
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alberta
MH  - Cognition Disorders/diagnosis/psychology/*therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Memory, Short-Term
MH  - Neuropsychological Tests/*statistics & numerical data
MH  - Pilot Projects
MH  - Psychometrics
MH  - Remedial Teaching/*methods
MH  - Risk
MH  - Schizophrenia/diagnosis/*therapy
MH  - *Schizophrenic Psychology
MH  - Schizotypal Personality Disorder/diagnosis/psychology/*therapy
MH  - Single-Blind Method
MH  - Young Adult
OTO - NOTNLM
OT  - Clinical high risk
OT  - Cognition
OT  - Cognitive remediation therapy
OT  - Functional outcome
EDAT- 2014/12/04 06:00
MHDA- 2015/05/27 06:00
CRDT- 2014/12/04 06:00
PHST- 2014/03/27 00:00 [received]
PHST- 2014/08/20 00:00 [revised]
PHST- 2014/10/25 00:00 [accepted]
PHST- 2014/12/04 06:00 [entrez]
PHST- 2014/12/04 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
AID - S0165-1781(14)00847-6 [pii]
AID - 10.1016/j.psychres.2014.10.021 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Jan 30;225(1-2):93-98. doi: 10.1016/j.psychres.2014.10.021. 
      Epub 2014 Nov 4.