PMID- 25467734
OWN - NLM
STAT- MEDLINE
DCOM- 20150916
LR  - 20220318
IS  - 1744-8409 (Electronic)
IS  - 1744-666X (Linking)
VI  - 11
IP  - 2
DP  - 2015 Feb
TI  - Dendritic cell-based vaccine research against cancer.
PG  - 213-32
LID - 10.1586/1744666X.2015.987663 [doi]
AB  - Therapeutic vaccines that treat cancers with the help of the patient's own immune 
      system signify a feasible option for active immunotherapy against the disease. 
      Dendritic cells (DCs) play a central role in modulating the immune response and 
      thus can be wisely utilized as an immunotherapeutic strategy for cancer regimens. 
      Advances in the knowledge of DC biology and function have led to the development 
      of DC-based vaccines for cancer therapy. In the present review, we discuss the 
      biology and function of DCs, their subsets and receptors, antigen loading and 
      route of administration of DC vaccines, as well as active and passive targeting 
      strategies for treating the cancer. We also discuss the preclinical and clinical 
      status of these newly developed vaccines. Special attention should be given by 
      the scientific community to the challenges that need to be solved for the 
      successful implication of these vaccines in cancer therapy.
FAU - Mody, Nishi
AU  - Mody N
AD  - Department of Pharmaceutical Sciences, Drug Delivery Research Laboratory, Dr. H. 
      S. Gour University, Sagar, MP, India.
FAU - Dubey, Surbhi
AU  - Dubey S
FAU - Sharma, Rajeev
AU  - Sharma R
FAU - Agrawal, Udita
AU  - Agrawal U
FAU - Vyas, Suresh P
AU  - Vyas SP
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141203
PL  - England
TA  - Expert Rev Clin Immunol
JT  - Expert review of clinical immunology
JID - 101271248
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - *Biomedical Research
MH  - *Cancer Vaccines/immunology/therapeutic use
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Neoplasms/immunology/therapy
OTO - NOTNLM
OT  - DC subsets
OT  - cancer
OT  - dendritic cell
OT  - receptors
OT  - targeting
OT  - vaccination
EDAT- 2014/12/04 06:00
MHDA- 2015/09/17 06:00
CRDT- 2014/12/04 06:00
PHST- 2014/12/04 06:00 [entrez]
PHST- 2014/12/04 06:00 [pubmed]
PHST- 2015/09/17 06:00 [medline]
AID - 10.1586/1744666X.2015.987663 [doi]
PST - ppublish
SO  - Expert Rev Clin Immunol. 2015 Feb;11(2):213-32. doi: 
      10.1586/1744666X.2015.987663. Epub 2014 Dec 3.