PMID- 25468565
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20181113
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Print)
IS  - 0171-2985 (Linking)
VI  - 220
IP  - 4
DP  - 2015 Apr
TI  - Batf3 deficiency is not critical for the generation of CD8alpha(+) dendritic cells.
PG  - 518-24
LID - S0171-2985(14)00210-1 [pii]
LID - 10.1016/j.imbio.2014.10.019 [doi]
AB  - Recently, we have reported that CD8alpha(+) DCs, rather than CD8(+) T cells, are 
      involved in the establishment and maintenance of HSV-1 latency in the trigeminal 
      ganglia (TG) of ocularly infected mice. In the current study, we investigated 
      whether similar results can be obtained using Batf3(-/-) mice that previously 
      were reported to lack CD8alpha(+) DCs. However, our results demonstrate that 
      Batf3(-/-) mice, without any known infection, express CD8alpha(+) DCs. Consequently, 
      due to the presence of CD8alpha(+) DCs, no differences were detected in the level of 
      HSV-1 latency between Batf3(-/-) mice compared with wild type control mice.
CI  - Copyright (c) 2014 Elsevier GmbH. All rights reserved.
FAU - Mott, Kevin R
AU  - Mott KR
AD  - Center for Neurobiology and Vaccine Development, Ophthalmology Research, 
      Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
FAU - Maazi, Hadi
AU  - Maazi H
AD  - Department of Molecular Microbiology and Immunology, Keck School of Medicine, 
      University of Southern California, Los Angeles, CA, USA.
FAU - Allen, Sariah J
AU  - Allen SJ
AD  - Center for Neurobiology and Vaccine Development, Ophthalmology Research, 
      Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
FAU - Zandian, Mandana
AU  - Zandian M
AD  - Center for Neurobiology and Vaccine Development, Ophthalmology Research, 
      Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
FAU - Matundan, Harry
AU  - Matundan H
AD  - Center for Neurobiology and Vaccine Development, Ophthalmology Research, 
      Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
FAU - Ghiasi, Yasamin N
AU  - Ghiasi YN
AD  - Department of Molecular Microbiology and Immunology, Keck School of Medicine, 
      University of Southern California, Los Angeles, CA, USA.
FAU - Sharifi, Behrooz G
AU  - Sharifi BG
AD  - Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los 
      Angeles, CA, USA.
FAU - Underhill, David
AU  - Underhill D
AD  - Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical 
      Center, Los Angeles, CA, USA.
FAU - Akbari, Omid
AU  - Akbari O
AD  - Department of Molecular Microbiology and Immunology, Keck School of Medicine, 
      University of Southern California, Los Angeles, CA, USA.
FAU - Ghiasi, Homayon
AU  - Ghiasi H
AD  - Center for Neurobiology and Vaccine Development, Ophthalmology Research, 
      Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 
      Electronic address: ghiasih@cshs.org.
LA  - eng
GR  - R01 EY013615/EY/NEI NIH HHS/United States
GR  - R21 AI093941/AI/NIAID NIH HHS/United States
GR  - AI093941/AI/NIAID NIH HHS/United States
GR  - EY13615/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141030
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (CD8 Antigens)
RN  - 0 (CD8 antigen, alpha chain)
RN  - 0 (Repressor Proteins)
RN  - 0 (SNFT protein, mouse)
SB  - IM
MH  - Animals
MH  - Basic-Leucine Zipper Transcription Factors/*deficiency
MH  - CD8 Antigens/genetics/*metabolism
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Disease Models, Animal
MH  - Gene Knockout Techniques
MH  - Herpes Simplex/genetics/immunology/metabolism
MH  - Herpesvirus 1, Human/immunology
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - Mice
MH  - Mice, Knockout
MH  - Phenotype
MH  - Rabbits
MH  - Repressor Proteins/*deficiency
PMC - PMC4355210
MID - NIHMS639606
OTO - NOTNLM
OT  - Compensation
OT  - Dendritic cells
OT  - HSV-1
OT  - Knockout
OT  - Latency
EDAT- 2014/12/04 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/04/01
CRDT- 2014/12/04 06:00
PHST- 2014/06/26 00:00 [received]
PHST- 2014/09/17 00:00 [revised]
PHST- 2014/10/21 00:00 [accepted]
PHST- 2014/12/04 06:00 [entrez]
PHST- 2014/12/04 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - S0171-2985(14)00210-1 [pii]
AID - 10.1016/j.imbio.2014.10.019 [doi]
PST - ppublish
SO  - Immunobiology. 2015 Apr;220(4):518-24. doi: 10.1016/j.imbio.2014.10.019. Epub 
      2014 Oct 30.