PMID- 25470006
OWN - NLM
STAT- MEDLINE
DCOM- 20151214
LR  - 20220410
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 12
DP  - 2014
TI  - Genetic variation at the BDNF locus: evidence for association with long-term 
      outcome after ischemic stroke.
PG  - e114156
LID - 10.1371/journal.pone.0114156 [doi]
LID - e114156
AB  - BACKGROUND AND PURPOSE: Rates and extent of recovery after stroke vary 
      considerably between individuals and genetic factors are thought to contribute to 
      post-stroke outcome. Brain-derived neurotrophic factor (BDNF) plays important 
      roles in brain plasticity and repair and has been shown to be involved in stroke 
      severity, recovery, and outcome in animal models. Few clinical studies on BDNF 
      genotypes in relation to ischemic stroke have been performed. The aims of the 
      present study are therefore to investigate whether genetic variation at the BDNF 
      locus is associated with initial stroke severity, recovery and/or short-term and 
      long-term functional outcome after ischemic stroke. METHODS: Four BDNF tagSNPs 
      were analyzed in the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS; 600 
      patients and 600 controls, all aged 18-70 years). Stroke severity was assessed 
      using the NIH Stroke Scale (NIHSS). Stroke recovery was defined as the change in 
      NIHSS over a 3-month period. Short- and long-term functional outcome post-stroke 
      was assessed using the modified Rankin Scale at 3 months and at 2 and 7 years 
      after stroke, respectively. RESULTS: No SNP was associated with stroke severity 
      or recovery at 3 months and no SNP had an impact on short-term outcome. However, 
      rs11030119 was independently associated with poor functional outcome 7-years 
      after stroke (OR 0.66, 95% CI 0.46-0.92; P =  0.006). CONCLUSIONS: BDNF gene 
      variants were not major contributors to ischemic stroke severity, recovery, or 
      short-term functional outcome. However, this study suggests that variants in the 
      BDNF gene may contribute to poor long-term functional outcome after ischemic 
      stroke.
FAU - Stanne, Tara M
AU  - Stanne TM
AD  - Institute of Biomedicine, Section for Clinical Genetics, the Sahlgrenska Academy 
      at University of Gothenburg, Gothenburg, Sweden.
FAU - Tjarnlund-Wolf, Anna
AU  - Tjarnlund-Wolf A
AD  - Institute of Neuroscience and Physiology, Section for Clinical Neuroscience and 
      Rehabilitation, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, 
      Sweden.
FAU - Olsson, Sandra
AU  - Olsson S
AD  - Institute of Neuroscience and Physiology, Section for Clinical Neuroscience and 
      Rehabilitation, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, 
      Sweden.
FAU - Jood, Katarina
AU  - Jood K
AD  - Institute of Neuroscience and Physiology, Section for Clinical Neuroscience and 
      Rehabilitation, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, 
      Sweden.
FAU - Blomstrand, Christian
AU  - Blomstrand C
AD  - Institute of Neuroscience and Physiology, Section for Clinical Neuroscience and 
      Rehabilitation, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, 
      Sweden.
FAU - Jern, Christina
AU  - Jern C
AD  - Institute of Biomedicine, Section for Clinical Genetics, the Sahlgrenska Academy 
      at University of Gothenburg, Gothenburg, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141203
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Brain Ischemia/complications
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stroke/etiology/*genetics/pathology
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC4254920
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/12/04 06:00
MHDA- 2015/12/15 06:00
PMCR- 2014/12/03
CRDT- 2014/12/04 06:00
PHST- 2014/06/26 00:00 [received]
PHST- 2014/11/04 00:00 [accepted]
PHST- 2014/12/04 06:00 [entrez]
PHST- 2014/12/04 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2014/12/03 00:00 [pmc-release]
AID - PONE-D-14-28537 [pii]
AID - 10.1371/journal.pone.0114156 [doi]
PST - epublish
SO  - PLoS One. 2014 Dec 3;9(12):e114156. doi: 10.1371/journal.pone.0114156. 
      eCollection 2014.