PMID- 25470398 OWN - NLM STAT- MEDLINE DCOM- 20150921 LR - 20191027 IS - 1996-3181 (Electronic) IS - 1871-5273 (Linking) VI - 13 IP - 10 DP - 2014 TI - Effects of physical exercise on depressive symptoms and biomarkers in depression. PG - 1640-53 AB - Regular physical exercise/activity has been shown repeatedly to promote positive benefits in cognitive, emotional and motor domains concomitant with reductions in distress and negative affect. It exerts a preventative role in anxiety and depressive states and facilitates psychological well-being in both adolescents and adults. Not least, several meta-analyses attest to improvements brought about by exercise. In the present treatise, the beneficial effects of exercise upon cognitive, executive function and working memory, emotional, self-esteem and depressed mood, motivational, anhedonia and psychomotor retardation, and somatic/physical, sleep disturbances and chronic aches and pains, categories of depression are discussed. Concurrently, the amelioration of several biomarkers associated with depressive states: hypothalamic-pituitary-adrenal (HPA) axis homeostasis, anti-neurodegenerative effects, monoamine metabolism regulation and neuroimmune functioning. The notion that physical exercise may function as "scaffolding" that buttresses available network circuits, anti-inflammatory defences and neuroreparative processes, e.g. brain-derived neurotrophic factor (BDNF), holds a certain appeal. FAU - Archer, Trevor AU - Archer T FAU - Josefsson, Torbjorn AU - Josefsson T FAU - Lindwall, Magnus AU - Lindwall M AD - School of Social and Health Sciences, Halmstad University, Box 823, S-301 18 Halmstad, Sweden. Torbjorn.Josefsson@hh.se. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United Arab Emirates TA - CNS Neurol Disord Drug Targets JT - CNS & neurological disorders drug targets JID - 101269155 RN - 0 (Biomarkers) SB - IM MH - *Biomarkers MH - Depression/*metabolism/*rehabilitation MH - Exercise/*physiology MH - Exercise Therapy/*methods MH - Humans MH - Hypothalamo-Hypophyseal System/metabolism MH - Pituitary-Adrenal System/metabolism EDAT- 2014/12/04 06:00 MHDA- 2015/09/22 06:00 CRDT- 2014/12/04 06:00 PHST- 2014/04/24 00:00 [received] PHST- 2014/06/06 00:00 [revised] PHST- 2014/06/18 00:00 [accepted] PHST- 2014/12/04 06:00 [entrez] PHST- 2014/12/04 06:00 [pubmed] PHST- 2015/09/22 06:00 [medline] AID - CNSNDDT-EPUB-63693 [pii] AID - 10.2174/1871527313666141130203245 [doi] PST - ppublish SO - CNS Neurol Disord Drug Targets. 2014;13(10):1640-53. doi: 10.2174/1871527313666141130203245.