PMID- 25472559
OWN - NLM
STAT- MEDLINE
DCOM- 20160225
LR  - 20181113
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Linking)
VI  - 54
IP  - 4
DP  - 2015 Jun
TI  - Maternal vitamin C deficiency during pregnancy results in transient fetal and 
      placental growth retardation in guinea pigs.
PG  - 667-76
LID - 10.1007/s00394-014-0809-6 [doi]
AB  - PURPOSE: Recently, we reported that preferential maternal-fetal vitamin C (vitC) 
      transport across the placenta is likely to be impaired by prolonged maternal vitC 
      deficiency. Maintenance of a basal maternal vitC supply at the expense of the 
      fetus may impair fetal development; however, the knowledge of vitC's impact on 
      intrauterine development is sparse. The aim of this study was to explore the 
      effect of maternal vitC status on fetal and placental development in guinea pigs. 
      METHODS: Twenty pregnant Dunkin Hartley guinea pigs were randomized into four 
      groups to receive diets either sufficient (918 mg/kg CTRL) or deficient (100 
      mg/kg DEF) in vitC. Cesarean sections at gestational day (GD) 45 or 56 allowed 
      for fetal and placental measurements. RESULTS: At GD45, body, brain and placental 
      weights were significantly reduced in DEF pups compared with CTRL (p < 0.05, p < 
      0.001 and p < 0.05, respectively). DEF plasma vitC levels were ~6% of those of 
      CTRL (p < 0.0001), and the fetal/maternal plasma vitC ratio was significantly 
      reduced at GD56 in the DEF animals compared with controls (p = 0.035). Placental 
      vitC levels were reduced in DEF animals (p < 0.0001) and the ascorbate oxidation 
      ratio and glutathione elevated compared with controls (p < 0.0001). CONCLUSIONS: 
      Although no clinical differences between CTRL and DEF pups were observed at GD56, 
      the present data suggest that vitC plays a role in early fetal development. 
      Although no clinical differences between CTRL and DEF pups were observed at GD56, 
      the present data suggest that vitC plays a role in early fetal development. Low 
      maternal vitC intake during pregnancy may compromise maternal weight gain, 
      placental function and intrauterine development.
FAU - Schjoldager, Janne Gram
AU  - Schjoldager JG
AD  - Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, 
      University of Copenhagen, 9 Ridebanevej, 1870, Frederiksberg C, Denmark.
FAU - Paidi, Maya Devi
AU  - Paidi MD
FAU - Lindblad, Maiken Marie
AU  - Lindblad MM
FAU - Birck, Malene Muusfeldt
AU  - Birck MM
FAU - Kjaergaard, Astrid Birch
AU  - Kjaergaard AB
FAU - Dantzer, Vibeke
AU  - Dantzer V
FAU - Lykkesfeldt, Jens
AU  - Lykkesfeldt J
FAU - Tveden-Nyborg, Pernille
AU  - Tveden-Nyborg P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141204
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Sodium-Coupled Vitamin C Transporters)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
EIN - Eur J Nutr. 2015 Jun;54(4):677-8. PMID: 25930964
MH  - Animals
MH  - Ascorbic Acid/blood
MH  - Ascorbic Acid Deficiency/*blood
MH  - Diet
MH  - Disease Models, Animal
MH  - Euthanasia
MH  - Female
MH  - Fetal Development
MH  - Fetal Growth Retardation/*physiopathology
MH  - Fetus/*physiopathology
MH  - Guinea Pigs
MH  - Linear Models
MH  - *Maternal Nutritional Physiological Phenomena
MH  - Maternal-Fetal Exchange
MH  - Placenta/*physiopathology
MH  - Pregnancy
MH  - Sodium-Coupled Vitamin C Transporters/genetics/metabolism
EDAT- 2014/12/05 06:00
MHDA- 2016/02/26 06:00
CRDT- 2014/12/05 06:00
PHST- 2014/07/28 00:00 [received]
PHST- 2014/11/25 00:00 [accepted]
PHST- 2014/12/05 06:00 [entrez]
PHST- 2014/12/05 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - 10.1007/s00394-014-0809-6 [doi]
PST - ppublish
SO  - Eur J Nutr. 2015 Jun;54(4):667-76. doi: 10.1007/s00394-014-0809-6. Epub 2014 Dec 
      4.