PMID- 25473259
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141204
LR  - 20200930
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 8
DP  - 2014
TI  - Clinical application of optical coherence tomography in combination with 
      functional diagnostics: advantages and limitations for diagnosis and assessment 
      of therapy outcome in central serous chorioretinopathy.
PG  - 2337-45
LID - 10.2147/OPTH.S73119 [doi]
AB  - PURPOSE: While identifying functional and structural parameters of the retina in 
      central serous chorioretinopathy (CSCR) patients, this study investigated how an 
      optical coherence tomography (OCT)-based diagnosis can be significantly 
      supplemented with functional diagnostic tools and to what degree the 
      determination of disease severity and therapy outcome can benefit from 
      diagnostics complementary to OCT. METHODS: CSCR patients were evaluated 
      prospectively with microperimetry (MP) and spectral domain optical coherence 
      tomography (SD-OCT) to determine retinal sensitivity function and retinal 
      thickness as outcome measures along with measures of visual acuity (VA). Patients 
      received clinical care that involved focal laser photocoagulation or 
      pharmacotherapy targeting inflammation and neovascularization. RESULTS: 
      Correlation of clinical parameters with a focus on functional parameters, VA, and 
      mean retinal sensitivity, as well as on the structural parameter mean retinal 
      thickness, showed that functional measures were similar in diagnostic power. A 
      moderate correlation was found between OCT data and the standard functional 
      assessment of VA; however, a strong correlation between OCT and MP data showed 
      that diagnostic measures cannot always be used interchangeably, but that 
      complementary use is of higher clinical value. CONCLUSION: The study indicates 
      that integrating SD-OCT with MP provides a more complete diagnosis with high 
      clinical relevance for complex, difficult to quantify diseases such as CSCR.
FAU - Schliesser, Joshua A
AU  - Schliesser JA
AD  - Vision Research Center, Department of Ophthalmology, University of Missouri - 
      Kansas City, School of Medicine, Kansas City, MO, USA.
FAU - Gallimore, Gary
AU  - Gallimore G
AD  - Vision Research Center, Department of Ophthalmology, University of Missouri - 
      Kansas City, School of Medicine, Kansas City, MO, USA.
FAU - Kunjukunju, Nancy
AU  - Kunjukunju N
AD  - Vision Research Center, Department of Ophthalmology, University of Missouri - 
      Kansas City, School of Medicine, Kansas City, MO, USA.
FAU - Sabates, Nelson R
AU  - Sabates NR
AD  - Vision Research Center, Department of Ophthalmology, University of Missouri - 
      Kansas City, School of Medicine, Kansas City, MO, USA.
FAU - Koulen, Peter
AU  - Koulen P
AD  - Vision Research Center, Department of Ophthalmology, University of Missouri - 
      Kansas City, School of Medicine, Kansas City, MO, USA.
FAU - Sabates, Felix N
AU  - Sabates FN
AD  - Vision Research Center, Department of Ophthalmology, University of Missouri - 
      Kansas City, School of Medicine, Kansas City, MO, USA.
LA  - eng
PT  - Journal Article
DEP - 20141121
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC4247136
OTO - NOTNLM
OT  - microperimetry
OT  - ophthalmology
OT  - retina
OT  - spectral domain optical coherence tomography
OT  - structure-function
OT  - visual acuity
EDAT- 2014/12/05 06:00
MHDA- 2014/12/05 06:01
PMCR- 2014/11/21
CRDT- 2014/12/05 06:00
PHST- 2014/12/05 06:00 [entrez]
PHST- 2014/12/05 06:00 [pubmed]
PHST- 2014/12/05 06:01 [medline]
PHST- 2014/11/21 00:00 [pmc-release]
AID - opth-8-2337 [pii]
AID - 10.2147/OPTH.S73119 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2014 Nov 21;8:2337-45. doi: 10.2147/OPTH.S73119. eCollection 
      2014.