PMID- 25473336
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141204
LR  - 20240510
IS  - 1319-0164 (Print)
IS  - 2213-7475 (Electronic)
IS  - 1319-0164 (Linking)
VI  - 22
IP  - 5
DP  - 2014 Nov
TI  - Antioxidant and anti-inflammatory effects of Marrubium alysson extracts in high 
      cholesterol-fed rabbits.
PG  - 472-82
LID - 10.1016/j.jsps.2013.12.004 [doi]
AB  - The antioxidant and anti-inflammatory effects of hexane (HEXA), chloroform 
      (CHLORO), ethyl acetate (EA) and total alcoholic (T. ALCOH) extracts of Marrubium 
      alysson in hypercholesterolemic-fed rabbits were evaluated. Hypercholesterolemia 
      was induced in male rabbits by high cholesterol diet (HCD) (350 mg/kg) for 
      8 weeks. Hypercholesterolemic rabbits were allocated into groups, treated with 
      simvastatin (SIM 5 mg/kg), different extracts of M. alysson at two doses of 250, 
      500 mg/kg. A normal control group and an HCD control one were used for 
      comparison. Lipid profile, as well as oxidized low density 
      lipoprotein-cholesterol (ox-LDL-C), myeloperoxidase activity (MPO) and superoxide 
      anion production (O2*(-)), C-reactive protein (CRP) and monocyte chemoattractant 
      protein-1 (MCP-1) were also evaluated. In addition, histological examination of 
      ascending aorta was performed. We found dyslipidemia associated with significant 
      increases in ox-LDL-C 123.5 +/- 9.8 nmol MDA/mg non-HDL, MPO activity 
      0.08 +/- 0.05 U/100 mg tissue and O2*(-) production 3.5 +/- 0.3 nmol cytochrome C 
      reduced/min/g tissue x 10(-4) in hypercholerterolemic rabbits. In addition, there 
      was a significant increase in CRP 6.6 +/- 0.49 mumol/L and MCP-1 190.9 +/- 6.4 pg/ml 
      and its mRNA expression in HCD. Intima appeared thick with thick plaques 
      surrounding the intima and luminal narrowing. SIM, EA and HEXA extracts of M. 
      alysson had lipid lowering effect, decrease in ox-LDL-C, MPO, O2*(-), CRP and 
      MCP-1 mRNA expression with improvement of the pathological picture. M. alysson 
      enhanced the stability of plaque, had lipid lowering, anti-inflammatory and 
      antioxidant activities.
FAU - Essawy, Soha S
AU  - Essawy SS
AD  - Department of Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, 
      Egypt.
FAU - Abo-Elmatty, Dina M
AU  - Abo-Elmatty DM
AD  - Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 
      Egypt.
FAU - Ghazy, Nabila M
AU  - Ghazy NM
AD  - Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, 
      Alexandria, Egypt.
FAU - Badr, Jihan M
AU  - Badr JM
AD  - Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, 
      King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Pharmacognosy, 
      Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
FAU - Sterner, Olov
AU  - Sterner O
AD  - Department of Organic Chemistry 2, Lund University, P.O. Box 124, S-21100 Lund, 
      Sweden.
LA  - eng
PT  - Journal Article
DEP - 20131221
PL  - Saudi Arabia
TA  - Saudi Pharm J
JT  - Saudi pharmaceutical journal : SPJ : the official publication of the Saudi 
      Pharmaceutical Society
JID - 9705695
PMC - PMC4246394
OTO - NOTNLM
OT  - Anti-inflammatory
OT  - Antioxidant
OT  - Hypercholesterolemia
OT  - Marrubium alysson
EDAT- 2014/12/05 06:00
MHDA- 2014/12/05 06:01
PMCR- 2013/12/21
CRDT- 2014/12/05 06:00
PHST- 2013/09/13 00:00 [received]
PHST- 2013/12/14 00:00 [accepted]
PHST- 2014/12/05 06:00 [entrez]
PHST- 2014/12/05 06:00 [pubmed]
PHST- 2014/12/05 06:01 [medline]
PHST- 2013/12/21 00:00 [pmc-release]
AID - S1319-0164(13)00115-1 [pii]
AID - 10.1016/j.jsps.2013.12.004 [doi]
PST - ppublish
SO  - Saudi Pharm J. 2014 Nov;22(5):472-82. doi: 10.1016/j.jsps.2013.12.004. Epub 2013 
      Dec 21.