PMID- 25475594
OWN - NLM
STAT- MEDLINE
DCOM- 20150803
LR  - 20240325
IS  - 1534-6307 (Electronic)
IS  - 1523-3774 (Print)
IS  - 1523-3774 (Linking)
VI  - 17
IP  - 1
DP  - 2015 Jan
TI  - Biomarkers for childhood-onset systemic lupus erythematosus.
PG  - 471
LID - 10.1007/s11926-014-0471-2 [doi]
AB  - Childhood-onset systemic lupus erythematosus (cSLE) is a systemic autoimmune 
      disease characterized by the presence of autoantibodies. cSLE often affects 
      multiple organs in the body and is known to have a poorer prognosis than 
      adult-onset disease (Azevedo et al. 2014). Current laboratory tests are clearly 
      insufficient for identifying and monitoring the disease. Recent studies have 
      yielded novel biomarkers for cSLE which can be used for monitoring disease 
      activity and response to treatment. The most encouraging biomarkers will be 
      discussed herein and include cell-bound complement activation products, some 
      genomic profiles, and urinary proteins such as neutrophil gelatinase-associated 
      lipocalin, monocyte chemoattractant protein-1, and others. Previous studies 
      suggested that a combination of the novel biomarkers might help to enhance 
      sensitivity and specificity for early diagnosis, disease monitoring, and 
      prediction of cSLE flares.
FAU - Abulaban, Khalid M
AU  - Abulaban KM
AD  - Division of Pediatric Rheumatology, Cincinnati Children's Hospital Medical 
      Center, MLC 4010, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA, 
      Khalid.Abulaban@cchmc.org.
FAU - Brunner, Hermine I
AU  - Brunner HI
LA  - eng
GR  - P50 DK096418/DK/NIDDK NIH HHS/United States
GR  - UL1 TR000077/TR/NCATS NIH HHS/United States
GR  - UL1 TR001425/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Rheumatol Rep
JT  - Current rheumatology reports
JID - 100888970
RN  - 0 (Biomarkers)
SB  - IM
MH  - Age of Onset
MH  - Biomarkers/*analysis
MH  - Cardiovascular Diseases/diagnosis
MH  - Child
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*diagnosis
MH  - Lupus Nephritis/diagnosis
MH  - Lupus Vasculitis, Central Nervous System/diagnosis
PMC - PMC4980820
MID - NIHMS800947
COIS- Conflict of Interest Khalid M Abulaban and Hermine I. Brunner declare no 
      conflicts of interest.
EDAT- 2014/12/06 06:00
MHDA- 2015/08/04 06:00
PMCR- 2016/08/11
CRDT- 2014/12/06 06:00
PHST- 2014/12/06 06:00 [entrez]
PHST- 2014/12/06 06:00 [pubmed]
PHST- 2015/08/04 06:00 [medline]
PHST- 2016/08/11 00:00 [pmc-release]
AID - 10.1007/s11926-014-0471-2 [doi]
PST - ppublish
SO  - Curr Rheumatol Rep. 2015 Jan;17(1):471. doi: 10.1007/s11926-014-0471-2.