PMID- 2547563
OWN - NLM
STAT- MEDLINE
DCOM- 19890914
LR  - 20181113
IS  - 0012-6667 (Print)
IS  - 0012-6667 (Linking)
VI  - 37 Suppl 1
DP  - 1989
TI  - The effect of nedocromil sodium on human eosinophil activation.
PG  - 19-22; discussion 69-77
AB  - Nedocromil sodium inhibited the increase in eosinophil activation (measured by 
      IgG- and complement-dependent cytotoxicity assays) induced by platelet activating 
      factor (PAF). Inhibition of the upregulation in eosinophil effector function by 
      nedocromil sodium was dose-dependent (optimal at 10(-7) mol/L) and paralleled 
      that produced by a specific PAF antagonist, BN 52021. In addition, preliminary 
      data suggest that nedocromil sodium can inhibit the increase in IgG-dependent 
      release of LTC4 from human eosinophils after stimulation with the synthetic 
      tripeptide, formyl-methionyl-leucyl-phenylalanine (fMLP). These data support our 
      previous hypothesis that part of the mode of action of nedocromil sodium may be 
      due to its ability to directly block the chemotactic factor-induced enhancement 
      of inflammatory cell activity.
FAU - Moqbel, R
AU  - Moqbel R
AD  - Department of Allergy and Clinical Immunology, National Heart and Lung Institute, 
      London, United Kingdom.
FAU - Cromwell, O
AU  - Cromwell O
FAU - Kay, A B
AU  - Kay AB
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Drugs
JT  - Drugs
JID - 7600076
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Platelet Activating Factor)
RN  - 0 (Quinolones)
RN  - 0B535E0BN0 (Nedocromil)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Cell Adhesion/drug effects
MH  - Cell Survival/drug effects
MH  - Eosinophils/*drug effects/immunology
MH  - Humans
MH  - In Vitro Techniques
MH  - Nedocromil
MH  - Phagocytosis/drug effects
MH  - Platelet Activating Factor/pharmacology
MH  - Quinolones/*pharmacology
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.2165/00003495-198900371-00005 [doi]
PST - ppublish
SO  - Drugs. 1989;37 Suppl 1:19-22; discussion 69-77. doi: 
      10.2165/00003495-198900371-00005.