PMID- 25475686
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20191210
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 586
DP  - 2015 Jan 23
TI  - Memantine exerts functional recovery by improving BDNF and GDNF expression in 
      3-nitropropionic acid intoxicated mice.
PG  - 1-7
LID - S0304-3940(14)00914-8 [pii]
LID - 10.1016/j.neulet.2014.11.036 [doi]
AB  - Memantine (MN), a NMDA blocker is well known for its protective effect against 
      various neurodegenerative diseases. However, its role in improving motor function 
      and regulation of neurotrophic factors in Huntington's disease (HD) has not been 
      studied yet. In the present study, we have investigated the effect of MN against 
      3-nitropropionic acid (3NP), induced motor impairment, and alterations in the 
      expression of brain-derived neurotrophic factor (BDNF) and glial cell-derived 
      neurotrophic factor (GDNF) in mice brain. Further, its role in mitochondrial 
      function was assessed by measuring succinate dehydrogenase (SDH) activity. Glial 
      fibrillary acidic protein (GFAP) and neuronal nuclei (NeuN) immunoreactivity were 
      studied to evaluate the role of MN on glial and neuronal function. Its effect on 
      apoptosis was adjudged by studying the expression of apoptotic markers. MN 
      restored motor functions with an associated up-regulation in neurotrophin 
      expression. MN also enhanced brain SDH activity and decreased glutamate content. 
      MN ameliorated striatal neuronal loss, reduced GFAP immunoreactivity, and 
      exhibited protective effect against neuronal apoptosis. Data from the current 
      study demonstrated that MN exerted neuroprotective effect against 3NP induced 
      neuropathology. Restoration of motor function by MN might be through regulation 
      of neurotrophin expression. MN can therefore be a useful therapeutic choice in 
      the symptomatic management of HD.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Ranju, Vijayan
AU  - Ranju V
AD  - Centre for Toxicology and Developmental Research, Sri Ramachandra University, 
      Chennai 600116, India; Department of Biotechnology, Dr. M.G.R. Educational and 
      Research Institute, Maduravoyal, Chennai 600095, India.
FAU - Sathiya, Sekar
AU  - Sathiya S
AD  - Centre for Toxicology and Developmental Research, Sri Ramachandra University, 
      Chennai 600116, India; Department of Biotechnology, Dr. M.G.R. Educational and 
      Research Institute, Maduravoyal, Chennai 600095, India.
FAU - Kalaivani, Periyathambi
AU  - Kalaivani P
AD  - Centre for Toxicology and Developmental Research, Sri Ramachandra University, 
      Chennai 600116, India.
FAU - Priya, Raju Jyothi
AU  - Priya RJ
AD  - Centre for Toxicology and Developmental Research, Sri Ramachandra University, 
      Chennai 600116, India.
FAU - Saravana Babu, Chidambaram
AU  - Saravana Babu C
AD  - Centre for Toxicology and Developmental Research, Sri Ramachandra University, 
      Chennai 600116, India. Electronic address: ceftpublications@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141202
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (NeuN protein, mouse)
RN  - 0 (Nitro Compounds)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Propionates)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - EC 1.3.99.1 (Succinate Dehydrogenase)
RN  - QY4L0FOX0D (3-nitropropionic acid)
RN  - W8O17SJF3T (Memantine)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Brain/cytology/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - DNA-Binding Proteins
MH  - Glial Cell Line-Derived Neurotrophic Factor/*metabolism
MH  - Male
MH  - Memantine/*pharmacology
MH  - Mice, Inbred C57BL
MH  - Motor Activity/*drug effects
MH  - Nerve Tissue Proteins/metabolism
MH  - Nitro Compounds/*toxicity
MH  - Nuclear Proteins/metabolism
MH  - Propionates/*toxicity
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
MH  - Succinate Dehydrogenase/metabolism
OTO - NOTNLM
OT  - 3NP
OT  - BDNF
OT  - GDNF
OT  - GFAP
OT  - Memantine
OT  - NeuN
EDAT- 2014/12/06 06:00
MHDA- 2015/05/15 06:00
CRDT- 2014/12/06 06:00
PHST- 2014/09/04 00:00 [received]
PHST- 2014/11/18 00:00 [revised]
PHST- 2014/11/25 00:00 [accepted]
PHST- 2014/12/06 06:00 [entrez]
PHST- 2014/12/06 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - S0304-3940(14)00914-8 [pii]
AID - 10.1016/j.neulet.2014.11.036 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 Jan 23;586:1-7. doi: 10.1016/j.neulet.2014.11.036. Epub 2014 
      Dec 2.