PMID- 25476192
OWN - NLM
STAT- MEDLINE
DCOM- 20150728
LR  - 20141205
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 34
IP  - 12
DP  - 2014 Dec
TI  - Dietary early-life exposure to contaminated eels does not impair spatial 
      cognitive performances in adult offspring mice as assessed in the Y-maze and the 
      Morris water maze.
PG  - 1075-84
LID - S0271-5317(14)00096-7 [pii]
LID - 10.1016/j.nutres.2014.06.011 [doi]
AB  - Many environmental contaminants are introduced via the diet and may act as 
      neurotoxins and endocrine disrupters, especially influencing growing organisms in 
      early life. The purpose of this study was to examine whether dietary exposure of 
      dams to fish naturally contaminated with xenobiotics, especially with 
      polychlorinated biphenyls (PCBs) and heavy metals (e.g., mercury and lead), 
      resulted in cognitive function deficits in adult offspring mice. Daily, four 
      groups of dams (n = 10/group) ingested standard diet plus paste with/without 
      eels, during gestation and lactation, from gestational day (GD) six until post 
      natal day (PND) 21 (weaning). Dams orally ingested a standardized amount of eel 
      (0.8 mg kg(-1) d(-1)) containing the six non-dioxin-like (NDL) PCBs (Sigma6 NDL-PCBs: 
      28, 52, 101, 138, 153, and 180) at 0, 85, 216, and 400 ng kg(-1) d(-1). Results 
      showed that early-life exposure to contaminated eels did not (compared to 
      non-exposed controls) impair immediate working memory in the Y-maze in the 
      offspring assessed at PND 38. Furthermore, it did not significantly impact 
      spatial learning and retention memory as measured in the Morris water maze in 
      adult offspring mice (PND 120-123). Our results suggest that perinatal exposure 
      to contaminated eels does not affect spatial cognitive performances, as assessed 
      by the Y-maze and Morris water maze at adult age. Adverse effects of xenobiotics 
      reported earlier might be camouflaged by beneficial eel constituents, such as n-3 
      fatty acids. However, additional studies are needed to differentiate between 
      potential positive and negative effects following consumption of food items both 
      rich in nutrients and contaminants.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Dridi, Imen
AU  - Dridi I
AD  - Universite de Lorraine, Neurotoxicologie Alimentaire et Bioactivite, MRCA/UR 
      AFPA/INRA, BP 4102, 57040 Metz, France; Unite de Biochimie des Lipides et 
      Interaction des Macromolecules en Biologie (03/UR/0902), Laboratoire de Biochimie 
      et Biologie Moleculaire, Faculte des Sciences de Bizerte, Zarzouna, Bizerte, 
      Tunisia.
FAU - Leroy, Delphine
AU  - Leroy D
AD  - Universite de Liege, CART (Center for Analytical and Research Technology), LEAE 
      (Laboratory of Animal Ecology and Ecotoxicology), B-4000 Sart-Tilman, Belgium.
FAU - Guignard, Cedric
AU  - Guignard C
AD  - Centre de Recherche Public - Gabriel Lippmann, Environment and 
      Agro-Biotechnologies Department, 41, rue du Brill, L-4422 Belvaux, Luxembourg.
FAU - Scholl, Georges
AU  - Scholl G
AD  - Universite de Liege, CART (Center for Analytical and Research Technology), LEAE 
      (Laboratory of Animal Ecology and Ecotoxicology), B-4000 Sart-Tilman, Belgium.
FAU - Bohn, Torsten
AU  - Bohn T
AD  - Centre de Recherche Public - Gabriel Lippmann, Environment and 
      Agro-Biotechnologies Department, 41, rue du Brill, L-4422 Belvaux, Luxembourg.
FAU - Landoulsi, Ahmed
AU  - Landoulsi A
AD  - Unite de Biochimie des Lipides et Interaction des Macromolecules en Biologie 
      (03/UR/0902), Laboratoire de Biochimie et Biologie Moleculaire, Faculte des 
      Sciences de Bizerte, Zarzouna, Bizerte, Tunisia.
FAU - Thome, Jean-Pierre
AU  - Thome JP
AD  - Universite de Liege, CART (Center for Analytical and Research Technology), LEAE 
      (Laboratory of Animal Ecology and Ecotoxicology), B-4000 Sart-Tilman, Belgium.
FAU - Eppe, Gauthier
AU  - Eppe G
AD  - Universite de Liege, CART (Center for Analytical and Research Technology), LEAE 
      (Laboratory of Animal Ecology and Ecotoxicology), B-4000 Sart-Tilman, Belgium.
FAU - Soulimani, Rachid
AU  - Soulimani R
AD  - Universite de Lorraine, Neurotoxicologie Alimentaire et Bioactivite, MRCA/UR 
      AFPA/INRA, BP 4102, 57040 Metz, France.
FAU - Bouayed, Jaouad
AU  - Bouayed J
AD  - Universite de Lorraine, Neurotoxicologie Alimentaire et Bioactivite, MRCA/UR 
      AFPA/INRA, BP 4102, 57040 Metz, France. Electronic address: 
      jaouad.bouayed@univ-lorraine.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140626
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Metals, Heavy)
RN  - 0 (Water Pollutants, Chemical)
RN  - 0 (Xenobiotics)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult Children
MH  - Animals
MH  - Cognition/*drug effects
MH  - Diet
MH  - Eels
MH  - Female
MH  - *Food Contamination
MH  - Lactation
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Memory/*drug effects
MH  - Metals, Heavy/*adverse effects
MH  - Mice
MH  - Polychlorinated Biphenyls/*adverse effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - *Seafood
MH  - Water Pollutants, Chemical/adverse effects
MH  - Xenobiotics/adverse effects
OTO - NOTNLM
OT  - Cognitive performances
OT  - Contaminants
OT  - Eels
OT  - Fatty fish
OT  - Methylmercury
OT  - PCBs
EDAT- 2014/12/06 06:00
MHDA- 2015/07/29 06:00
CRDT- 2014/12/06 06:00
PHST- 2014/03/15 00:00 [received]
PHST- 2014/06/12 00:00 [revised]
PHST- 2014/06/19 00:00 [accepted]
PHST- 2014/12/06 06:00 [entrez]
PHST- 2014/12/06 06:00 [pubmed]
PHST- 2015/07/29 06:00 [medline]
AID - S0271-5317(14)00096-7 [pii]
AID - 10.1016/j.nutres.2014.06.011 [doi]
PST - ppublish
SO  - Nutr Res. 2014 Dec;34(12):1075-84. doi: 10.1016/j.nutres.2014.06.011. Epub 2014 
      Jun 26.