PMID- 2547647
OWN - NLM
STAT- MEDLINE
DCOM- 19890914
LR  - 20130523
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 2
IP  - 5
DP  - 1989 May
TI  - The molecular genetics of human lung cancer.
PG  - 461-9
AB  - With the development of molecular biological techniques the search for genetic 
      alterations in cancer cells has resulted in the beginning of a molecular 
      description of cellular transformation. Most of these genetic changes occur in 
      genes which have a role in the control of cellular growth and development, the 
      proto oncogenes. In the last decade, it has become clear that the myc and ras 
      oncogene families are important in the carcinogenesis of human lung cancers. The 
      myc oncogenes are usually found to be altered in small cell lung cancer (SCLC), 
      and these alterations appear to correlate with rapid growth and progression. 
      Mutations in the Kras gene are specific for adenocarcinoma, a subclass of non 
      small cell lung cancer (NSCLC). Kras gene mutations are closely associated with 
      tobacco smoking, since all were found in adenocarcinomas from patients with a 
      history of smoking. The erbB oncogene, which encodes the epidermal growth factor 
      receptor, is often highly expressed in epidermoid carcinomas. The roles for other 
      oncogenes, such as raf or myb, as well as those of "suppressor" genes remain to 
      be investigated, but may be of paramount importance. The study of alterations in 
      proto oncogenes may aid in the (sub)classification and diagnosis of lung cancer, 
      and may yield useful prognostic information in the near future.
FAU - Slebos, R J
AU  - Slebos RJ
AD  - Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam.
FAU - Rodenhuis, S
AU  - Rodenhuis S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
CIN - Eur Respir J. 1989 Nov;2(10):1022. PMID: 2606191
MH  - Carcinoma, Non-Small-Cell Lung/*genetics
MH  - Carcinoma, Small Cell/*genetics
MH  - Genes, ras
MH  - Humans
MH  - Lung Neoplasms/*genetics
MH  - Oncogenes
MH  - *Proto-Oncogenes
MH  - Suppression, Genetic
RF  - 87
EDAT- 1989/05/01 00:00
MHDA- 1989/05/01 00:01
CRDT- 1989/05/01 00:00
PHST- 1989/05/01 00:00 [pubmed]
PHST- 1989/05/01 00:01 [medline]
PHST- 1989/05/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 1989 May;2(5):461-9.