PMID- 25476569
OWN - NLM
STAT- MEDLINE
DCOM- 20151203
LR  - 20181113
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 9
DP  - 2014 Dec 5
TI  - Mucinous tubular and spindle cell carcinoma and solid variant papillary renal 
      cell carcinoma: a clinicopathologic comparative analysis of four cases with 
      similar molecular genetics datum.
PG  - 194
LID - 10.1186/s13000-014-0194-8 [doi]
LID - 194
AB  - Mucinous tubular and spindle cell carcinoma (MTSC) was first recognized as a 
      specific entity in the World Health Organization 2004 classification. The 
      "classic" tumor presentation includes an extracellular blue-gray mucinous/myxoid 
      matrix accompanying the typical tubular and spindle cell epithelial components. 
      Tubules are lined by cuboidal to columnar cells with bland nuclei, central small 
      to medium sized nucleoli, and few to no mitoses. By expanding the histologic 
      spectrum, a number of studies highlighted the distinction between MTSC and solid 
      variant of papillary renal cell carcinoma (sPRCC), although controversy still 
      exists. Here, we evaluated two cases of MTSC and compared two cases of sPRCC by 
      light microscopy, special staining, immunohistochemical staining and fluorescence 
      in situ hybridization (FISH). We found that morphologic and immunophenotyping 
      features showed more overlap between MTSC and sPRCC. In addition, gains of 
      chromosomes 7 and 17 and loss of Y, which are characteristic of PRCC, were 
      observed in two cases of sPRCC and one case of MTSC, suggesting that MTSC is 
      similar to sPRCC or may be a subtype of PRCC. Virtual Slides: The virtual 
      slide(s) for this article can be found here: 
      http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_194.
FAU - Zhang, Yanling
AU  - Zhang Y
AD  - Department of Pathology, the Frist Affiliated Hospital of Bengbu Medical College, 
      287 Changhuai Road, 233000, Bengbu, Anhui, PR China. zhangyanling1204@163.com.
FAU - Yong, Xiang
AU  - Yong X
AD  - Department of Pathology, the Frist Affiliated Hospital of Bengbu Medical College, 
      287 Changhuai Road, 233000, Bengbu, Anhui, PR China. ydh2210@163.com.
FAU - Wu, Qiong
AU  - Wu Q
AD  - Department of Pathology, the Frist Affiliated Hospital of Bengbu Medical College, 
      287 Changhuai Road, 233000, Bengbu, Anhui, PR China. 694699155@qq.com.
FAU - Wang, Xiaoli
AU  - Wang X
AD  - Department of Pathology, the Frist Affiliated Hospital of Bengbu Medical College, 
      287 Changhuai Road, 233000, Bengbu, Anhui, PR China. 1558679005@qq.com.
FAU - Zhang, Qiong
AU  - Zhang Q
AD  - Department of Pathology, the Frist Affiliated Hospital of Bengbu Medical College, 
      287 Changhuai Road, 233000, Bengbu, Anhui, PR China. 473444289@qq.com.
FAU - Wu, Shiwu
AU  - Wu S
AD  - Department of Pathology, the Frist Affiliated Hospital of Bengbu Medical College, 
      287 Changhuai Road, 233000, Bengbu, Anhui, PR China. yongxiangkaoyan@163.com.
FAU - Yu, Donghong
AU  - Yu D
AD  - Department of Pathology, the Frist Affiliated Hospital of Bengbu Medical College, 
      287 Changhuai Road, 233000, Bengbu, Anhui, PR China. 273513439@qq.com.
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141205
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adenocarcinoma, Mucinous/chemistry/*diagnosis/genetics/pathology
MH  - Aged
MH  - Biomarkers, Tumor/genetics
MH  - Carcinoma, Renal Cell/chemistry/*diagnosis/genetics/pathology
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 7
MH  - Chromosomes, Human, Y
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/chemistry/*diagnosis/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Tomography, X-Ray Computed
PMC - PMC4262063
EDAT- 2014/12/06 06:00
MHDA- 2015/12/15 06:00
PMCR- 2014/12/05
CRDT- 2014/12/06 06:00
PHST- 2014/08/09 00:00 [received]
PHST- 2014/10/07 00:00 [accepted]
PHST- 2014/12/06 06:00 [entrez]
PHST- 2014/12/06 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2014/12/05 00:00 [pmc-release]
AID - s13000-014-0194-8 [pii]
AID - 194 [pii]
AID - 10.1186/s13000-014-0194-8 [doi]
PST - epublish
SO  - Diagn Pathol. 2014 Dec 5;9:194. doi: 10.1186/s13000-014-0194-8.