PMID- 25478193
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141205
LR  - 20220409
IS  - 2052-4439 (Print)
IS  - 2052-4439 (Electronic)
IS  - 2052-4439 (Linking)
VI  - 1
IP  - 1
DP  - 2014
TI  - An evaluation of factors associated with completion and benefit from pulmonary 
      rehabilitation in COPD.
PG  - e000051
LID - 10.1136/bmjresp-2014-000051 [doi]
LID - e000051
AB  - BACKGROUND: Pulmonary Rehabilitation (PR) is an important treatment for patients 
      with chronic obstructive pulmonary disease (COPD) but it is not established 
      whether any baseline parameter can predict response or compliance. AIM: To 
      identify whether baseline measures can predict who will complete the programme 
      and who will achieve a clinically significant benefit from a Minimum Clinical 
      Important Difference (MCID) in terms of exercise capacity and health-related 
      quality of life (HRQoL). METHODS: Data were collected prospectively from patients 
      with COPD at their baseline assessment for an outpatient PR programme in one of 
      eight centres across London. 'Completion' was defined as attending at least 75% 
      of the designated PR visits and return for the follow-up evaluation. The MCID for 
      outcome measures was based on published data. RESULTS: 787 outpatients with COPD 
      (68.1+/-10.5 years old; 49.6% males) were included. Patients who completed PR 
      (n=449, 57.1%) were significantly older with less severe airflow obstruction, 
      lower anxiety and depression scores, less dyspnoea and better HRQoL. Only 
      baseline CAT score (OR=0.925; 95% CI 0.879 to 0.974; p=0.003) was retained in 
      multivariate analysis. Patients with the lowest baseline walking distance were 
      most likely to achieve the MCID for exercise capacity. No baseline variable could 
      independently predict achievement of an MCID in HRQoL. CONCLUSIONS: Patients with 
      better HRQoL are more likely to complete PR while worse baseline exercise 
      performance makes the achievement of a positive MCID in exercise capacity more 
      likely. However, no baseline parameter could predict who would benefit the most 
      in terms of HRQoL.
FAU - Boutou, Afroditi K
AU  - Boutou AK
AD  - The NIHR Respiratory Biomedical Research Unit , Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College , London , UK.
FAU - Tanner, Rebecca J
AU  - Tanner RJ
AD  - The NIHR Respiratory Biomedical Research Unit , Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College , London , UK.
FAU - Lord, Victoria M
AU  - Lord VM
AD  - The NIHR Respiratory Biomedical Research Unit , Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College , London , UK.
FAU - Hogg, Lauren
AU  - Hogg L
AD  - Guy's and St Thomas' Foundation NHS Trust , London , UK.
FAU - Nolan, Jane
AU  - Nolan J
AD  - St George's Hospital NHS Trust , London , UK.
FAU - Jefford, Helen
AU  - Jefford H
AD  - Greenwich Adult Community Health Services, London , UK.
FAU - Corner, Evelyn J
AU  - Corner EJ
AD  - Chelsea and Westminster NHS Foundation Trust , London , UK.
FAU - Falzon, Christine
AU  - Falzon C
AD  - Central London Community Healthcare , London , UK.
FAU - Lee, Cassandra
AU  - Lee C
AD  - Imperial College Healthcare NHS Trust , London , UK.
FAU - Garrod, Rachel
AU  - Garrod R
AD  - King's College Hospital NHS Foundation Trust , London , UK.
FAU - Polkey, Michael I
AU  - Polkey MI
AD  - The NIHR Respiratory Biomedical Research Unit , Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College , London , UK.
FAU - Hopkinson, Nicholas S
AU  - Hopkinson NS
AUID- ORCID: 0000-0003-3235-0454
AD  - The NIHR Respiratory Biomedical Research Unit , Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College , London , UK.
LA  - eng
GR  - MC_PC_12032/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20141103
PL  - England
TA  - BMJ Open Respir Res
JT  - BMJ open respiratory research
JID - 101638061
PMC - PMC4242085
OTO - NOTNLM
OT  - Pulmonary Rehabilitation
EDAT- 2014/12/06 06:00
MHDA- 2014/12/06 06:01
PMCR- 2014/11/03
CRDT- 2014/12/06 06:00
PHST- 2014/06/05 00:00 [received]
PHST- 2014/08/31 00:00 [revised]
PHST- 2014/09/01 00:00 [accepted]
PHST- 2014/12/06 06:00 [entrez]
PHST- 2014/12/06 06:00 [pubmed]
PHST- 2014/12/06 06:01 [medline]
PHST- 2014/11/03 00:00 [pmc-release]
AID - bmjresp-2014-000051 [pii]
AID - 10.1136/bmjresp-2014-000051 [doi]
PST - epublish
SO  - BMJ Open Respir Res. 2014 Nov 3;1(1):e000051. doi: 10.1136/bmjresp-2014-000051. 
      eCollection 2014.