PMID- 25478501 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20141205 LR - 20200930 IS - 2251-9572 (Print) IS - 2251-9580 (Electronic) IS - 2251-9572 (Linking) VI - 2 IP - 2 DP - 2013 May TI - Coronary Flow Assessment in Unstable Angina/non ST-segment Elevation Myocardial Infarction Patients via Thrombolysis in Myocardial Infarction Frame Count in Angiography. PG - 95-8 LID - 10.5812/cardiovascmed.9087 [doi] AB - BACKGROUND: TIMI Frame Count (TFC) is one of the methods to estimate the coronary blood flow velocity. This is a simple, inexpensive, quantitative, reproducible, and continuous variable method. Many studies have been conducted on TFC assessment in ST elevation myocardial infarction (STEMI) patients. OBJECTIVES: The present study is aimed to measure the TFC in the coronary arteries of UA/NSTEMI patients to find abnormalities in diseased or patent vessels and compare with the normal values. PATIENTS AND METHODS: The participants were 105 consecutive UA/NSTEMI patients who underwent coronary angiography in Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, Iran in 2009. Exclusion criteria were history of CABG, PCI, or STEMI or presence of occluded arteries in angiography. We measured the coronary TFC in these patients. We examined also 55 stable patients without coronary lesions and with TIMI 3 flow to have an estimation of normal TFCs. RESULTS: From a total of 105 patients, 25 (23.8%) had no significant coronary lesion (> 60%); 35 (33.3%) were diagnosed with single vessel disease; 22 (21%) were 2VD; and 23 (21.9%) were 3 VD.). In overall, mean TFC in UA/NSTEMI group was 28.7 (+/- 14) frames compared to 23.8 (+/- 7.8) frames in the normal group (P < 0.05). In the vessels with significant lesions, TFC was significantly higher than normal (30.84 vs. 23.8; P < 0.001) and also significantly higher than patent vessels of the same patients (30.84 vs. 26.10; P = 0.029). In these patients, patent vessels had higher TFC values compared to normal coronaries (26.10 vs. 23.8), but the difference was not significant (P = 0.12). In the patients with significant lesions, mean TFC was higher than the same value in acute coronary patients without significant lesions (29.3 vs. 27.2), but the difference was not significant (P = 0.114). In the patients who underwent PCI and stenting, TFC changed significantly after PCI toward the normal value (P = 0.001). In the patients with elevated cardiac enzymes, TFC was higher but the difference was not significant (P = 0.35). CONCLUSIONS: Patent coronaries of UA/NSTEMI patients have a trend to higher TFCs compared to normal values. Presence of significant coronary lesions in these patients significantly increases TFC. FAU - Sanati, Hamidreza AU - Sanati H AD - Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. FAU - Zahedmehr, Ali AU - Zahedmehr A AD - Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. FAU - Firouzi, Ata AU - Firouzi A AD - Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. FAU - Salehi, Negar AU - Salehi N AD - Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. FAU - Maadani, Mohsen AU - Maadani M AD - Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. FAU - Shakerian, Farshad AU - Shakerian F AD - Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. FAU - Kiani, Reza AU - Kiani R AD - Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. FAU - Golnari, Pedram AU - Golnari P AD - Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. FAU - Parchami-Ghazaee, Sepideh AU - Parchami-Ghazaee S AD - Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. FAU - Peighambari, Mohammadmehdi AU - Peighambari M AD - Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. LA - eng PT - Journal Article DEP - 20130520 PL - India TA - Res Cardiovasc Med JT - Research in cardiovascular medicine JID - 101608315 PMC - PMC4253762 OTO - NOTNLM OT - Angina, Unstable OT - Coronary Angiography OT - Myocardial Infarction EDAT- 2013/05/01 00:00 MHDA- 2013/05/01 00:01 PMCR- 2013/05/01 CRDT- 2014/12/06 06:00 PHST- 2012/11/12 00:00 [received] PHST- 2012/12/15 00:00 [revised] PHST- 2012/12/16 00:00 [accepted] PHST- 2014/12/06 06:00 [entrez] PHST- 2013/05/01 00:00 [pubmed] PHST- 2013/05/01 00:01 [medline] PHST- 2013/05/01 00:00 [pmc-release] AID - 10.5812/cardiovascmed.9087 [doi] PST - ppublish SO - Res Cardiovasc Med. 2013 May;2(2):95-8. doi: 10.5812/cardiovascmed.9087. Epub 2013 May 20.