PMID- 25478993
OWN - NLM
STAT- MEDLINE
DCOM- 20151204
LR  - 20171116
IS  - 1557-8593 (Electronic)
IS  - 1520-9156 (Linking)
VI  - 17
IP  - 2
DP  - 2015 Feb
TI  - Metabolic obesity, adipocytokines, and inflammatory markers in Asian 
      Indians--CURES-124.
PG  - 134-41
LID - 10.1089/dia.2014.0202 [doi]
AB  - AIM: This study looked at the association of adipokines, inflammatory and 
      oxidative stress markers in subjects with the following phenotypes: metabolically 
      healthy, nonobese (MHNO), metabolically healthy, obese (MHO), metabolically 
      obese, nonobese (MONO), and metabolically obese, obese (MOO). MATERIALS AND 
      METHODS: Subjects with MHNO (n=462), MHO (n=192), MONO (n=315), and MOO (n=335) 
      were randomly selected from the Chennai Urban Rural Epidemiology Study. 
      Adiponectin, visfatin, resistin, high-sensitivity C-reactive protein (hs-CRP), 
      tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), oxidized low-density 
      lipoprotein (LDL), and monocyte chemoattractant protein-1 (MCP-1) were measured 
      by enzyme-linked immunosorbent assay. RESULTS: Levels of adiponectin were lowest 
      in the MOO group, followed by the MONO, MHO, and the MHNO groups (P=0.042), 
      whereas the levels of visfatin (P=0.042) and resistin (P=0.043) were highest in 
      the MOO group, followed by the MONO, MHO, and the MHNO groups. Levels of hs-CRP 
      (P=0.029), TNF-alpha (P=0.036), IL-6 (P=0.042), oxidized LDL (P=0.036), and MCP-1 
      (P=0.039) increased from the MHNO to MHO to MONO to MOO phenotypes. Linear 
      regression analysis of the parameters with body mass index (BMI) and metabolic 
      syndrome components showed that adiponectin is negatively associated with 
      abdominal obesity (beta=-0.060; P=0.039) and BMI (beta=-0.076; P=0.009) and that TNF-alpha 
      is negatively associated with high-density lipoprotein levels (beta=0.114, P=0.049) 
      even after adjusting for age and gender. hs-CRP (beta=0.112, P=0.020) and oxidized 
      LDL (beta=0.114, P=0.050) showed a positive association with systolic blood pressure 
      even after adjusting for age and gender. CONCLUSIONS: The metabolically obese 
      phenotype is characterized by altered adipokine and inflammatory profiles, which 
      could make this phenotype at high risk for type 2 diabetes mellitus and 
      cardiovascular diseases.
FAU - Indulekha, Karunakaran
AU  - Indulekha K
AD  - Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, 
      WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, 
      International Diabetes Federation Centre of Education , Gopalapuram, Chennai, 
      India .
FAU - Surendar, Jayagopi
AU  - Surendar J
FAU - Anjana, Ranjit Mohan
AU  - Anjana RM
FAU - Geetha, Loganathan
AU  - Geetha L
FAU - Gokulakrishnan, Kuppan
AU  - Gokulakrishnan K
FAU - Pradeepa, Rajendra
AU  - Pradeepa R
FAU - Mohan, Viswanathan
AU  - Mohan V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141205
PL  - United States
TA  - Diabetes Technol Ther
JT  - Diabetes technology & therapeutics
JID - 100889084
RN  - 0 (Blood Glucose)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - C-Reactive Protein/metabolism
MH  - Coronary Artery Disease/blood/*epidemiology/immunology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*epidemiology/immunology
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Inflammation/blood/*epidemiology
MH  - Interleukin-6/metabolism
MH  - Linear Models
MH  - Male
MH  - Metabolic Syndrome/blood/*epidemiology/immunology
MH  - Middle Aged
MH  - Obesity/*epidemiology/genetics/immunology
MH  - Oxidative Stress
MH  - Prevalence
MH  - Tumor Necrosis Factor-alpha
EDAT- 2014/12/06 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/12/06 06:00
PHST- 2014/12/06 06:00 [entrez]
PHST- 2014/12/06 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1089/dia.2014.0202 [doi]
PST - ppublish
SO  - Diabetes Technol Ther. 2015 Feb;17(2):134-41. doi: 10.1089/dia.2014.0202. Epub 
      2014 Dec 5.