PMID- 25479119
OWN - NLM
STAT- MEDLINE
DCOM- 20150331
LR  - 20220311
IS  - 1933-0693 (Electronic)
IS  - 0022-3085 (Linking)
VI  - 122
IP  - 2
DP  - 2015 Feb
TI  - Quality of life following surgery for large and giant vestibular schwannomas: a 
      prospective study.
PG  - 303-11
LID - 10.3171/2014.10.JNS14534 [doi]
AB  - OBJECT: Prospective studies of quality of life (QOL) are infrequently performed 
      in patients undergoing surgery for vestibular schwannoma (VS). The authors 
      designed this to study to investigate health-related QOL (HR-QOL) in patients 
      with large and giant VSs before and after surgery. METHODS: Between January 2009 
      and December 2012, HR-QOL was measured prospectively before and after surgery, 
      using the 36-Item Short Form Health Survey (SF-36), in 100 patients who underwent 
      surgery for unilateral large or giant VS (tumor size>/=3 cm). The Glasgow Benefit 
      Inventory (GBI) was also used to evaluate the effect of surgery. RESULTS: A total 
      of 100 patients were included in the study (65 men and 35 women). Their mean age 
      (+/-SD) was 44.2+/-11.5 years. The preoperative QOL was decreased in all SF-36 
      domains. A 1-year follow-up evaluation was conducted for all patients (mean 
      13.5+/-5.3 months after surgery). The results showed an improvement in HR-QOL 
      compared with preoperative status in all cases, with 63%-85% of patients showing 
      a minimum clinically important difference (MCID) in various domains. A second 
      follow-up evaluation was performed in 51 cases (mean time after surgery, 29.0+/-8.3 
      months) and showed sustained improvement in SF-36 scores. In some domains there 
      was further improvement beyond the first follow-up. On the GBI, 87% of patients 
      reported improvement, 1% felt no change, and 12% of patients reported 
      deterioration. CONCLUSIONS: Patients harboring large or giant VSs score lower on 
      all the QOL domains compared with the normative population. More than 60% showed 
      a clinically significant improvement in HR-QOL 1 year after surgery, a result 
      that was sustained at subsequent follow-up.
FAU - Turel, Mazda K
AU  - Turel MK
AD  - Department of Neurological Sciences, Christian Medical College, Vellore, Tamil 
      Nadu, India.
FAU - Thakar, Sumit
AU  - Thakar S
FAU - Rajshekhar, Vedantam
AU  - Rajshekhar V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141205
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cranial Nerve Neoplasms/pathology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Glasgow Outcome Scale
MH  - Health Status
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mental Health
MH  - Middle Aged
MH  - Neuroma, Acoustic/pathology/*surgery
MH  - *Neurosurgical Procedures
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Treatment Outcome
MH  - *Tumor Burden
MH  - Young Adult
OTO - NOTNLM
OT  - CN = cranial nerve
OT  - GBI = Glasbow Benefit Inventory
OT  - Glasgow Benefit Inventory
OT  - HR-QOL = health-related QOL
OT  - MCID = minimum clinically important difference
OT  - QOL = quality of life
OT  - SEM = standard error of measurement
OT  - SF=36 = 36-Item Short Form Health Survey
OT  - Short-Form 36
OT  - VS = vestibular schwannoma
OT  - brain tumor
OT  - oncology
OT  - quality of life
OT  - surgery
EDAT- 2014/12/06 06:00
MHDA- 2015/04/01 06:00
CRDT- 2014/12/06 06:00
PHST- 2014/12/06 06:00 [entrez]
PHST- 2014/12/06 06:00 [pubmed]
PHST- 2015/04/01 06:00 [medline]
AID - 10.3171/2014.10.JNS14534 [doi]
PST - ppublish
SO  - J Neurosurg. 2015 Feb;122(2):303-11. doi: 10.3171/2014.10.JNS14534. Epub 2014 Dec 
      5.