PMID- 25479255
OWN - NLM
STAT- MEDLINE
DCOM- 20160425
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 12
DP  - 2014
TI  - Effects of maternal LPS exposure during pregnancy on metabolic phenotypes in 
      female offspring.
PG  - e114780
LID - 10.1371/journal.pone.0114780 [doi]
LID - e114780
AB  - It is increasingly recognized that intra-uterine growth restriction (IUGR) is 
      associated with an increased risk of metabolic disorders in late life. Previous 
      studies showed that mice exposed to LPS in late gestation induced fetal IUGR. The 
      present study investigated the effects of maternal LPS exposure during pregnancy 
      on metabolic phenotypes in female adult offspring. Pregnant mice were 
      intraperitoneally injected with LPS (50 microg/kg) daily from gestational day (GD)15 
      to GD17. After lactation, female pups were fed with standard-chow diets (SD) or 
      high-fat diets (HFD). Glucose tolerance test (GTT) and insulin tolerance test 
      (ITT) were assessed 8 and 12 weeks after diet intervention. Hepatic triglyceride 
      content was examined 12 weeks after diet intervention. As expected, maternal LPS 
      exposure during pregnancy resulted in fetal IUGR. Although there was an 
      increasing trend on fat mass in female offspring whose dams were exposed to LPS 
      during pregnancy, maternal LPS exposure during pregnancy did not elevate the 
      levels of fasting blood glucose and serum insulin and hepatic triglyceride 
      content in female adult offspring. Moreover, maternal LPS exposure during 
      pregnancy did not alter insulin sensitivity in adipose tissue and liver in female 
      adult offspring. Further analysis showed that maternal LPS exposure during 
      pregnancy did not exacerbate HFD-induced glucose tolerance and insulin resistance 
      in female adult offspring. In addition, maternal LPS exposure during pregnancy 
      did not aggravate HFD-induced elevation of hepatic triglyceride content in female 
      adult offspring. In conclusion, LPS-induced IUGR does not alter metabolic 
      phenotypes in adulthood.
FAU - Liu, Xiao-Jing
AU  - Liu XJ
AD  - Department of Toxicology, Anhui Medical University, Hefei, China; Anhui 
      Provincial Key Laboratory of Population Health & Aristogenics, Anhui Medical 
      University, Hefei, China; First Affiliated Hospital, Anhui Medical University, 
      Hefei, China.
FAU - Wang, Bi-Wei
AU  - Wang BW
AD  - Department of Toxicology, Anhui Medical University, Hefei, China.
FAU - Zhao, Mei
AU  - Zhao M
AD  - Anhui Provincial Key Laboratory of Population Health & Aristogenics, Anhui 
      Medical University, Hefei, China.
FAU - Zhang, Cheng
AU  - Zhang C
AD  - Department of Toxicology, Anhui Medical University, Hefei, China.
FAU - Chen, Yuan-Hua
AU  - Chen YH
AD  - Department of Toxicology, Anhui Medical University, Hefei, China; Anhui 
      Provincial Key Laboratory of Population Health & Aristogenics, Anhui Medical 
      University, Hefei, China.
FAU - Hu, Chun-Qiu
AU  - Hu CQ
AD  - Department of Toxicology, Anhui Medical University, Hefei, China.
FAU - Zhao, Hui
AU  - Zhao H
AD  - Second Affiliated Hospital, Anhui Medical University, Hefei, China.
FAU - Wang, Hua
AU  - Wang H
AD  - Department of Toxicology, Anhui Medical University, Hefei, China; Anhui 
      Provincial Key Laboratory of Population Health & Aristogenics, Anhui Medical 
      University, Hefei, China.
FAU - Chen, Xi
AU  - Chen X
AD  - First Affiliated Hospital, Anhui Medical University, Hefei, China.
FAU - Tao, Fang-Biao
AU  - Tao FB
AD  - Anhui Provincial Key Laboratory of Population Health & Aristogenics, Anhui 
      Medical University, Hefei, China.
FAU - Xu, De-Xiang
AU  - Xu DX
AD  - Department of Toxicology, Anhui Medical University, Hefei, China; Anhui 
      Provincial Key Laboratory of Population Health & Aristogenics, Anhui Medical 
      University, Hefei, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141205
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Insulin)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Body Weight
MH  - Diet, High-Fat/adverse effects
MH  - Female
MH  - Fetal Growth Retardation/*metabolism
MH  - Insulin/blood/metabolism
MH  - *Insulin Resistance
MH  - Lipid Metabolism
MH  - Lipopolysaccharides/*toxicity
MH  - Liver/metabolism/pathology
MH  - Male
MH  - *Maternal Exposure
MH  - Metabolic Diseases/etiology/metabolism
MH  - Mice, Inbred ICR
MH  - Obesity/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Triglycerides/metabolism
PMC - PMC4257726
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/12/06 06:00
MHDA- 2016/04/26 06:00
PMCR- 2014/12/05
CRDT- 2014/12/06 06:00
PHST- 2014/08/08 00:00 [received]
PHST- 2014/11/13 00:00 [accepted]
PHST- 2014/12/06 06:00 [entrez]
PHST- 2014/12/06 06:00 [pubmed]
PHST- 2016/04/26 06:00 [medline]
PHST- 2014/12/05 00:00 [pmc-release]
AID - PONE-D-14-35819 [pii]
AID - 10.1371/journal.pone.0114780 [doi]
PST - epublish
SO  - PLoS One. 2014 Dec 5;9(12):e114780. doi: 10.1371/journal.pone.0114780. 
      eCollection 2014.