PMID- 25479464
OWN - NLM
STAT- MEDLINE
DCOM- 20150820
LR  - 20151119
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 90
DP  - 2015 Mar
TI  - Lack of GABAB receptors modifies behavioural and biochemical alterations induced 
      by precipitated nicotine withdrawal.
PG  - 90-101
LID - S0028-3908(14)00429-8 [pii]
LID - 10.1016/j.neuropharm.2014.11.013 [doi]
AB  - The nicotine (NIC) withdrawal syndrome is considered to be a major cause of the 
      high relapse rate among individuals undergoing smoking cessation. The aim of the 
      present study was to evaluate a possible role of GABAB receptors in NIC 
      withdrawal, by comparing GABAB1 knockout mice and their wild-type littermates. We 
      analysed the time course of the global withdrawal score, the anxiety-like 
      effects, monoamine concentrations, the brain-derived neurotrophic factor (BDNF) 
      expression, the corticosterone plasmatic levels and [(3)H]epibatidine binding 
      sites during NIC withdrawal precipitated by mecamylamine, a nicotinic receptor 
      antagonist (MEC). In NIC withdrawn wild-type mice, we observed a global 
      withdrawal score, an anxiety-like effect in the elevated plus maze, a decrease of 
      the striatal dopamine and 3,4-dihydroxyphenylacetic acid concentrations, an 
      increase of corticosterone plasma levels, a reduction of BDNF expression in 
      several brain areas and an increase of [(3)H]epibatidine binding sites in 
      specific brain regions. Interestingly, the effects found in NIC withdrawn 
      wild-type mice were absent in GABAB1 knockout mice, suggesting that GABAB1 
      subunit of the GABAB receptor is involved in the regulation of the behavioural 
      and biochemical alterations induced by NIC withdrawal in mice. These results 
      reveal an interaction between the GABAB receptors and the neurochemical systems 
      through which NIC exerts its long-term effects.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Varani, Andres P
AU  - Varani AP
AD  - Instituto de Investigaciones Farmacologicas (CONICET), Junin 956, 5 degrees  Piso, Buenos 
      Aires C1113AAD, Argentina.
FAU - Pedron, Valeria T
AU  - Pedron VT
AD  - Instituto de Investigaciones Farmacologicas (CONICET), Junin 956, 5 degrees  Piso, Buenos 
      Aires C1113AAD, Argentina.
FAU - Machado, Lirane Moutinho
AU  - Machado LM
AD  - Instituto de Investigaciones Farmacologicas (CONICET), Junin 956, 5 degrees  Piso, Buenos 
      Aires C1113AAD, Argentina.
FAU - Antonelli, Marta C
AU  - Antonelli MC
AD  - Instituto de Quimica y Fisicoquimica Biologicas (UBA-CONICET), Facultad de 
      Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina.
FAU - Bettler, Bernhard
AU  - Bettler B
AD  - Department of Biomedicine, Institute of Physiology, Pharmazentrum, University of 
      Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
FAU - Balerio, Graciela N
AU  - Balerio GN
AD  - Instituto de Investigaciones Farmacologicas (CONICET), Junin 956, 5 degrees  Piso, Buenos 
      Aires C1113AAD, Argentina; Catedra de Farmacologia, Facultad de Farmacia y 
      Bioquimica, Universidad de Buenos Aires, Junin 956, 5 degrees  Piso, Buenos Aires 
      C1113AAD, Argentina. Electronic address: gbalerio@ffyb.uba.ar.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141203
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gabrb1 protein, mouse)
RN  - 0 (Nicotinic Agonists)
RN  - 0 (Nicotinic Antagonists)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Receptors, Nicotinic)
RN  - 6EE945D3OK (Mecamylamine)
RN  - 6M3C89ZY6R (Nicotine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Anxiety/physiopathology
MH  - Brain/drug effects/physiopathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone/blood
MH  - Disease Models, Animal
MH  - Male
MH  - Mecamylamine/pharmacology
MH  - Mice, Inbred BALB C
MH  - Mice, Knockout
MH  - Nicotine/pharmacology
MH  - Nicotinic Agonists/pharmacology
MH  - Nicotinic Antagonists/pharmacology
MH  - Receptors, GABA-A/*deficiency/genetics
MH  - Receptors, Nicotinic/metabolism
MH  - Substance Withdrawal Syndrome/*physiopathology
MH  - Tobacco Use Disorder/drug therapy/*physiopathology
OTO - NOTNLM
OT  - Anxiety
OT  - BDNF
OT  - Corticosterone
OT  - Epibatidine
OT  - GABA(B) receptor
OT  - Mice
OT  - Monoamines
OT  - Nicotine
OT  - Withdrawal
EDAT- 2014/12/06 06:00
MHDA- 2015/08/21 06:00
CRDT- 2014/12/06 06:00
PHST- 2014/07/18 00:00 [received]
PHST- 2014/11/19 00:00 [revised]
PHST- 2014/11/22 00:00 [accepted]
PHST- 2014/12/06 06:00 [entrez]
PHST- 2014/12/06 06:00 [pubmed]
PHST- 2015/08/21 06:00 [medline]
AID - S0028-3908(14)00429-8 [pii]
AID - 10.1016/j.neuropharm.2014.11.013 [doi]
PST - ppublish
SO  - Neuropharmacology. 2015 Mar;90:90-101. doi: 10.1016/j.neuropharm.2014.11.013. 
      Epub 2014 Dec 3.