PMID- 25479766
OWN - NLM
STAT- MEDLINE
DCOM- 20150814
LR  - 20220311
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 61
DP  - 2015 Feb
TI  - Exploring neural dysfunction in 'clinical high risk' for psychosis: a 
      quantitative review of fMRI studies.
PG  - 122-34
LID - S0022-3956(14)00261-1 [pii]
LID - 10.1016/j.jpsychires.2014.08.018 [doi]
AB  - Individuals at clinical high risk (CHR) of developing psychosis present with 
      widespread functional abnormalities in the brain. Cognitive deficits, including 
      working memory (WM) problems, as commonly elicited by n-back tasks, are observed 
      in CHR individuals. However, functional MRI (fMRI) studies, comprising a 
      heterogeneous cluster of general and social cognition paradigms, have not 
      necessarily demonstrated consistent and conclusive results in this population. 
      Hence, a comprehensive review of fMRI studies, spanning almost one decade, was 
      carried out to observe for general trends with respect to brain regions and 
      cognitive systems most likely to be dysfunctional in CHR individuals. 32 studies 
      were included for this review, out of which 22 met the criteria for quantitative 
      analysis using activation likelihood estimation (ALE). Task related contrast 
      activations were firstly analysed by comparing CHR and healthy control 
      participants in the total pooled sample, followed by a comparison of general 
      cognitive function studies (excluding social cognition paradigms), and finally by 
      only looking at n-back working memory task based studies. Findings from the ALE 
      implicated four key dysfunctional and distinct neural regions in the CHR group, 
      namely the right inferior parietal lobule (rIPL), the left medial frontal gyrus 
      (lmFG), the left superior temporal gyrus (lSTG) and the right fronto-polar cortex 
      (rFPC) of the superior frontal gyrus (SFG). Narrowing down to relatively few 
      significant dysfunctional neural regions is a step forward in reducing the 
      apparent ambiguity of overall findings, which would help to target specific 
      neural regions and pathways of interest for future research in CHR populations.
CI  - Copyright (c) 2014. Published by Elsevier Ltd.
FAU - Dutt, Anirban
AU  - Dutt A
AD  - Institute of Psychiatry, King's College London, London, UK. Electronic address: 
      Anirban.Dutt@kcl.ac.uk.
FAU - Tseng, Huai-Hsuan
AU  - Tseng HH
AD  - Institute of Psychiatry, King's College London, London, UK.
FAU - Fonville, Leon
AU  - Fonville L
AD  - Institute of Psychiatry, King's College London, London, UK.
FAU - Drakesmith, Mark
AU  - Drakesmith M
AD  - Cardiff University Brain Research Imaging Centre, Cardiff, UK.
FAU - Su, Liang
AU  - Su L
AD  - Institute of Psychiatry, King's College London, London, UK.
FAU - Evans, John
AU  - Evans J
AD  - Cardiff University Brain Research Imaging Centre, Cardiff, UK.
FAU - Zammit, Stanley
AU  - Zammit S
AD  - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff 
      University, Cardiff, UK.
FAU - Jones, Derek
AU  - Jones D
AD  - Cardiff University Brain Research Imaging Centre, Cardiff, UK.
FAU - Lewis, Glyn
AU  - Lewis G
AD  - Division of Psychiatry, University College London, London, UK.
FAU - David, Anthony S
AU  - David AS
AD  - Institute of Psychiatry, King's College London, London, UK. Electronic address: 
      anthony.david@kcl.ac.uk.
LA  - eng
GR  - G0801418/MRC_/Medical Research Council/United Kingdom
GR  - G0901885/MRC_/Medical Research Council/United Kingdom
GR  - MR/L010305/1/MRC_/Medical Research Council/United Kingdom
GR  - MRC G0901885/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140930
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Adult
MH  - Brain/*physiopathology
MH  - Brain Mapping/methods
MH  - Cognition
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/*statistics & numerical data
MH  - *Likelihood Functions
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Memory, Short-Term
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Psychotic Disorders/diagnosis/*physiopathology/*psychology
MH  - Social Perception
OTO - NOTNLM
OT  - At-risk mental state
OT  - Clinical high risk
OT  - Meta-analysis
OT  - Psychosis
OT  - Review
OT  - fMRI
EDAT- 2014/12/07 06:00
MHDA- 2015/08/15 06:00
CRDT- 2014/12/07 06:00
PHST- 2014/03/23 00:00 [received]
PHST- 2014/08/06 00:00 [revised]
PHST- 2014/08/26 00:00 [accepted]
PHST- 2014/12/07 06:00 [entrez]
PHST- 2014/12/07 06:00 [pubmed]
PHST- 2015/08/15 06:00 [medline]
AID - S0022-3956(14)00261-1 [pii]
AID - 10.1016/j.jpsychires.2014.08.018 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2015 Feb;61:122-34. doi: 10.1016/j.jpsychires.2014.08.018. Epub 
      2014 Sep 30.