PMID- 25480016
OWN - NLM
STAT- MEDLINE
DCOM- 20160404
LR  - 20220311
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 348
IP  - 1-2
DP  - 2015 Jan 15
TI  - The co-occurrence of multiple sclerosis and type 1 diabetes: shared aetiologic 
      features and clinical implication for MS aetiology.
PG  - 126-31
LID - S0022-510X(14)00746-1 [pii]
LID - 10.1016/j.jns.2014.11.019 [doi]
AB  - We reviewed the evidence for the co-occurrence of type 1 diabetes mellitus (T1D) 
      and multiple sclerosis (MS), and assessed the clinical significance of this 
      association and the shared aetiological features of the two diseases. T1D and MS 
      contribute considerably to the burden of autoimmune diseases in young adults. The 
      co-occurrence of MS and T1D has been reported by a number of studies, suggesting 
      that the two conditions share one or more aetiological components. Both 
      conditions have been associated with distinct human leukocyte antigen (HLA) 
      haplotypes but share a number of similarities in clinical, epidemiological and 
      immunological features, leading to suggestions of possible common mechanisms of 
      development. While underlying genetic factors may be important for the 
      co-occurrence of both conditions, some evidence suggests that environmental 
      factors such as vitamin D deficiency may also modulate an individual's risk for 
      the development of both conditions. Evidence on whether the co-occurrence of the 
      two autoimmune conditions will affect the disease course and severity of MS is 
      merely absent. Further studies need to be conducted to ascertain whether the 
      neuropathology associated with T1D might influence the disease course and 
      contribute to the severity of MS.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Tettey, Prudence
AU  - Tettey P
AD  - Menzies Research Institute Tasmania, University of Tasmania, Australia.
FAU - Simpson, Steve Jr
AU  - Simpson S Jr
AD  - Menzies Research Institute Tasmania, University of Tasmania, Australia.
FAU - Taylor, Bruce V
AU  - Taylor BV
AD  - Menzies Research Institute Tasmania, University of Tasmania, Australia.
FAU - van der Mei, Ingrid A F
AU  - van der Mei IA
AD  - Menzies Research Institute Tasmania, University of Tasmania, Australia. 
      Electronic address: ingrid.vandermei@utas.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141120
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - *Comorbidity
MH  - Diabetes Mellitus, Type 1/epidemiology/*etiology/genetics
MH  - Humans
MH  - Multiple Sclerosis/epidemiology/*etiology/genetics
OTO - NOTNLM
OT  - Autoimmune
OT  - Comorbidity
OT  - Latitudinal gradient
OT  - Multiple sclerosis
OT  - Type 1 diabetes
OT  - Ultraviolet radiation and vitamin D
EDAT- 2014/12/07 06:00
MHDA- 2016/04/05 06:00
CRDT- 2014/12/07 06:00
PHST- 2014/05/29 00:00 [received]
PHST- 2014/10/21 00:00 [revised]
PHST- 2014/11/14 00:00 [accepted]
PHST- 2014/12/07 06:00 [entrez]
PHST- 2014/12/07 06:00 [pubmed]
PHST- 2016/04/05 06:00 [medline]
AID - S0022-510X(14)00746-1 [pii]
AID - 10.1016/j.jns.2014.11.019 [doi]
PST - ppublish
SO  - J Neurol Sci. 2015 Jan 15;348(1-2):126-31. doi: 10.1016/j.jns.2014.11.019. Epub 
      2014 Nov 20.