PMID- 25481360
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20220330
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 139
DP  - 2015 Feb
TI  - Effects of different timing of stress on corticosterone, BDNF and memory in male 
      rats.
PG  - 459-67
LID - S0031-9384(14)00606-4 [pii]
LID - 10.1016/j.physbeh.2014.12.004 [doi]
AB  - Learning and memory seem to be affected by chronic stress. Previous reports have 
      considered chronic stress as a precipitating factor of different 
      neuropsychological disorders, while others reported neurobiological adaptations 
      following stress. The present study investigated the effects of chronic stress 
      before, after, and during learning on the changes of learning and memory, on 
      serum and hippocampal levels of corticosterone (CORT), brain-derived neurotrophic 
      factor (BDNF) and body weight in rats. Male Wistar rats were randomly divided 
      into four groups (n=10) including Control (Co), Stress-Learning-Rest (St-L-Re), 
      Rest-Learning-Stress (Re-L-St), and Stress-Learning-Stress (St-L-St) groups. The 
      chronic restraint stress was applied 6 h/day for 21 days. Moreover, the passive 
      avoidance test was used to assess memory deficit, 1, 7, and 21 days after 
      training. At the end of experiments, CORT and BDNF levels were measured. The 
      findings did not support adaptation in chronic stress conditions. The acquisition 
      time as well as the short and mid-term memories was significantly impaired in the 
      St-L-Re group. Short, mid, and long-term memories were significantly impaired in 
      the Re-L-St and St-L-St groups compared with the Co group, as a result of the 
      enhancement of CORT and reduction of BDNF levels. In the St-L-St group, changes 
      in memory functions were less pronounced than in the Re-L-St group. Also, body 
      weight declined following the chronic stress, while recovery period enhanced the 
      body weight gain in stressed rats. It can be concluded that a potential 
      time-dependent involvement of stress and recovery period on the level of BDNF. 
      Longer duration time of chronic stress might promote adaptive effects on memory 
      and CORT level.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Radahmadi, Maryam
AU  - Radahmadi M
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Alaei, Hojjatallah
AU  - Alaei H
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran. Electronic address: alaei@med.mui.ac.ir.
FAU - Sharifi, Mohammad Reza
AU  - Sharifi MR
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Hosseini, Nasrin
AU  - Hosseini N
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141204
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adaptation, Psychological/physiology
MH  - Animals
MH  - Avoidance Learning/physiology
MH  - Body Weight/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Chronic Disease
MH  - Corticosterone/*metabolism
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*physiopathology
MH  - Male
MH  - Memory/physiology
MH  - Memory Disorders/*physiopathology
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Restraint, Physical
MH  - Stress, Psychological/*physiopathology
OTO - NOTNLM
OT  - BDNF
OT  - Body weight
OT  - Corticosterone
OT  - Memory
OT  - Passive avoidance
OT  - Rat
OT  - Stress
EDAT- 2014/12/08 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/12/08 06:00
PHST- 2014/07/20 00:00 [received]
PHST- 2014/11/25 00:00 [revised]
PHST- 2014/12/02 00:00 [accepted]
PHST- 2014/12/08 06:00 [entrez]
PHST- 2014/12/08 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - S0031-9384(14)00606-4 [pii]
AID - 10.1016/j.physbeh.2014.12.004 [doi]
PST - ppublish
SO  - Physiol Behav. 2015 Feb;139:459-67. doi: 10.1016/j.physbeh.2014.12.004. Epub 2014 
      Dec 4.