PMID- 25481406
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20141227
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 19
DP  - 2015 Jan
TI  - The systemic milieu as a mediator of dietary influence on stem cell function 
      during ageing.
PG  - 53-64
LID - S1568-1637(14)00126-3 [pii]
LID - 10.1016/j.arr.2014.11.004 [doi]
AB  - The regenerative decline of organisms during ageing is linked to the reduced 
      proliferative activity, impaired function and exhaustion of tissue-specific stem 
      and progenitor cells. Studies using heterochronic parabiosis, involving the 
      surgical attachment of young and old organisms so that they share a common 
      vascular system, have revealed that the systemic environment has a profound 
      effect on stem cell function. In particular, specific youthful rejuvenating 
      circulatory factors reverse age-related declines in stem cell function, whereas 
      the old milieu contains inhibitory factors that impede stem cell function in 
      young animals. Similarly, the effects of certain dietary interventions, namely 
      calorie restriction, also induce a more youthful cellular and molecular phenotype 
      in ageing stem cells throughout the body. Further to this, there are key 
      molecular pathways involved in translating the availability of nutrients into 
      altered stem cell function, including signalling in the insulin and insulin-like 
      growth factor and mechanistic target of rapamycin (mTOR) pathways. In this 
      review, we discuss the potential role of dietary interventions to promote a more 
      rejuvenating systemic milieu in order to enhance stem cell function and promote 
      healthy ageing.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Murphy, Tytus
AU  - Murphy T
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, The 
      James Black Centre, 125 Coldharbour Lane, SE5 9NU London, United Kingdom. 
      Electronic address: tytus.murphy@kcl.ac.uk.
FAU - Thuret, Sandrine
AU  - Thuret S
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, The 
      James Black Centre, 125 Coldharbour Lane, SE5 9NU London, United Kingdom. 
      Electronic address: sandrine.1.thuret@kcl.ac.uk.
LA  - eng
GR  - MR/K500811/1/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141204
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Diet
MH  - Heart/growth & development/physiology
MH  - Hippocampus/growth & development/physiology
MH  - Humans
MH  - Liver/growth & development/physiology
MH  - Muscle, Skeletal/growth & development/physiology
MH  - Obesity/physiopathology
MH  - Parabiosis
MH  - Stem Cells/*physiology
OTO - NOTNLM
OT  - Ageing
OT  - Calorie restriction
OT  - Heterochronic parabiosis
OT  - IGF1
OT  - Stem cells
OT  - mTOR
EDAT- 2014/12/08 06:00
MHDA- 2015/08/25 06:00
CRDT- 2014/12/08 06:00
PHST- 2014/09/03 00:00 [received]
PHST- 2014/11/20 00:00 [revised]
PHST- 2014/11/26 00:00 [accepted]
PHST- 2014/12/08 06:00 [entrez]
PHST- 2014/12/08 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
AID - S1568-1637(14)00126-3 [pii]
AID - 10.1016/j.arr.2014.11.004 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2015 Jan;19:53-64. doi: 10.1016/j.arr.2014.11.004. Epub 2014 Dec 
      4.