PMID- 25482448
OWN - NLM
STAT- MEDLINE
DCOM- 20150310
LR  - 20141224
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 456
IP  - 1
DP  - 2015 Jan 2
TI  - Basic fibroblast growth factor induces miR-134 upregulation in astrocyte for cell 
      maturation.
PG  - 465-70
LID - S0006-291X(14)02149-4 [pii]
LID - 10.1016/j.bbrc.2014.11.108 [doi]
AB  - Evidence suggests that neuronal microRNAs (miRs) contribute to synaptic 
      plasticity, although a role of glial miRs have been unknown. Growth factors 
      including brain-derived neurotrophic factor (BDNF) regulate neuronal functions 
      via upregulation of miRs, while possible influences on expression/function of 
      glial miRs have not been fully understood. Here, we report that basic fibroblast 
      growth factor (bFGF) increased miR-134 expression in astrocyte. The miR-134 was 
      upregulated through stimulating extracellular signal-regulated kinase and 
      phosphatidylinositol 3-kinase signaling, because inhibitors for each signaling 
      blocked the miR-134 induction by bFGF. We also found upregulation of glial 
      fibrillary acidic protein (astrocyte marker) and decreased extracellular 
      concentration of glutamate after miR-134 overexpression and bFGF application, 
      suggesting that astroglial cell maturation is enhanced by bFGF through induction 
      of miR-134.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Numakawa, Tadahiro
AU  - Numakawa T
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan. Electronic 
      address: numakawa@ncnp.go.jp.
FAU - Nakajima, Shingo
AU  - Nakajima S
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
FAU - Yamamoto, Noriko
AU  - Yamamoto N
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
FAU - Ooshima, Yoshiko
AU  - Ooshima Y
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
FAU - Odaka, Haruki
AU  - Odaka H
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan; Department of 
      Life Science and Medical Bioscience, School of Advanced Science and Engineering, 
      Waseda University, Tokyo, Japan.
FAU - Hashido, Kazuo
AU  - Hashido K
AD  - Administrative Section of Radiation Protection, National Institute of 
      Neuroscience, NCNP, Tokyo, Japan.
FAU - Adachi, Naoki
AU  - Adachi N
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
FAU - Kunugi, Hiroshi
AU  - Kunugi H
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141204
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (MIRN134 microRNA, rat)
RN  - 0 (MicroRNAs)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Animals
MH  - Astrocytes/*cytology/metabolism
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Fibroblast Growth Factor 2/*metabolism
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Glutamic Acid/metabolism
MH  - Male
MH  - MicroRNAs/*metabolism
MH  - Neuroglia/metabolism
MH  - Neurons/metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphorylation
MH  - Rats
MH  - Rats, Wistar
MH  - Signal Transduction
MH  - Up-Regulation
OTO - NOTNLM
OT  - Astrocyte
OT  - BDNF
OT  - Glutamate
OT  - MicroRNA
OT  - bFGF
OT  - miR-134
EDAT- 2014/12/09 06:00
MHDA- 2015/03/11 06:00
CRDT- 2014/12/09 06:00
PHST- 2014/11/07 00:00 [received]
PHST- 2014/11/28 00:00 [accepted]
PHST- 2014/12/09 06:00 [entrez]
PHST- 2014/12/09 06:00 [pubmed]
PHST- 2015/03/11 06:00 [medline]
AID - S0006-291X(14)02149-4 [pii]
AID - 10.1016/j.bbrc.2014.11.108 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2015 Jan 2;456(1):465-70. doi: 
      10.1016/j.bbrc.2014.11.108. Epub 2014 Dec 4.