PMID- 25482921
OWN - NLM
STAT- MEDLINE
DCOM- 20151228
LR  - 20150224
IS  - 1166-7087 (Print)
IS  - 1166-7087 (Linking)
VI  - 25
IP  - 4
DP  - 2015 Mar
TI  - [The role of urinary markers in the assessment and follow-up of lower urinary 
      tract disorders: a literature review].
PG  - 188-99
LID - S1166-7087(14)00659-9 [pii]
LID - 10.1016/j.purol.2014.11.004 [doi]
AB  - OBJECTIVES: To conduct a literature review on the role of urinary biomarkers in 
      the initial assessment and follow-up of lower urinary tract symptoms. METHODS: A 
      literature review was conducted in August 2014 using the Medline/Pubmed database 
      limiting the search to work in English or French. RESULTS: Most studies were of 
      level of evidence 2 or 3 (prospective cohort, controlled or not) and mainly about 
      overactive bladder and bladder pain syndrome. Nerve Growth Factor (NGF) was the 
      most studied and apparently the most promising in the evaluation of overactive 
      bladder (OAB) and neurogenic detrusor overactivity (NDO). Urinary levels of ATP, 
      prostaglandin E2 (PGE2), Brain-Derived Neurotrophic Factor (BDNF) and some 
      cytokines were also significantly higher in most studies in patients with NDO or 
      OAB. Epidermal Growth Factor (EGF), Heparin-Binding EGF (HBEGF) and 
      Antiproliferative Factor (APF) were the most studied urinary markers in bladder 
      pain syndrome, with a significant increase (EGF APF) or decrease (HBEGF) in cases 
      of interstitial cystitis (compared to healthy controls). The urinary 
      N-terminal-telopeptide (NTx) could be predictive of a failed mid-urethral sling. 
      However, few studies reported the diagnostic values of the markers, their 
      association with urodynamic parameters were rarely evaluated and the existence of 
      a publication bias is likely. No randomized controlled study has so far compared 
      the urinary markers to urodynamic evaluation. CONCLUSION: In the future, urinary 
      markers could complete or replace urodynamic examination. However, to date, there 
      is no high level of evidence study comparing these markers to urodynamics and 
      their use can therefore not be recommended in daily practice.
CI  - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.
FAU - Peyronnet, B
AU  - Peyronnet B
AD  - Service d'urologie, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35000 Rennes, 
      France; Centre de reference maladies rares spina bifida, CHU de Rennes, 2, rue 
      Henri-Le-Guilloux, 35000 Rennes, France; Departement d'urologie, transplantation 
      renale et andrologie, CHU Rangueil, TSA50032, 31059 Toulouse, France. Electronic 
      address: peyronnetbenoit@hotmail.fr.
FAU - Bendavid, C
AU  - Bendavid C
AD  - Service de biochimie, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35000 Rennes, 
      France.
FAU - Manunta, A
AU  - Manunta A
AD  - Service d'urologie, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35000 Rennes, 
      France; Centre de reference maladies rares spina bifida, CHU de Rennes, 2, rue 
      Henri-Le-Guilloux, 35000 Rennes, France.
FAU - Damphousse, M
AU  - Damphousse M
AD  - Centre de reference maladies rares spina bifida, CHU de Rennes, 2, rue 
      Henri-Le-Guilloux, 35000 Rennes, France; Service de medecine physique et 
      reeducation, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35000 Rennes, France.
FAU - Cheensse, C
AU  - Cheensse C
AD  - Centre de reference maladies rares spina bifida, CHU de Rennes, 2, rue 
      Henri-Le-Guilloux, 35000 Rennes, France; Service de medecine physique et 
      reeducation, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35000 Rennes, France.
FAU - Brochard, C
AU  - Brochard C
AD  - Centre de reference maladies rares spina bifida, CHU de Rennes, 2, rue 
      Henri-Le-Guilloux, 35000 Rennes, France; Service de gastro-enterologie, CHU de 
      Rennes, 2, rue Henri-Le-Guilloux, 35000 Rennes, France.
FAU - Castel-Lacanal, E
AU  - Castel-Lacanal E
AD  - Service de medecine physique et reeducation, CHU de Toulouse, 1, avenue du 
      Professeur-Jean-Poulhes, 31400 Toulouse, France.
FAU - Siproudhis, L
AU  - Siproudhis L
AD  - Centre de reference maladies rares spina bifida, CHU de Rennes, 2, rue 
      Henri-Le-Guilloux, 35000 Rennes, France; Service de gastro-enterologie, CHU de 
      Rennes, 2, rue Henri-Le-Guilloux, 35000 Rennes, France.
FAU - Bensalah, K
AU  - Bensalah K
AD  - Service d'urologie, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35000 Rennes, 
      France.
FAU - Game, X
AU  - Game X
AD  - Departement d'urologie, transplantation renale et andrologie, CHU Rangueil, 
      TSA50032, 31059 Toulouse, France.
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Place des biomarqueurs urinaires dans le diagnostic et le suivi des troubles du 
      bas appareil urinaire: une revue de la litterature.
DEP - 20141118
PL  - France
TA  - Prog Urol
JT  - Progres en urologie : journal de l'Association francaise d'urologie et de la 
      Societe francaise d'urologie
JID - 9307844
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/urine
MH  - Follow-Up Studies
MH  - Humans
MH  - Lower Urinary Tract Symptoms/*diagnosis/*urine
OTO - NOTNLM
OT  - Biomarkers
OT  - Biomarqueurs
OT  - Detrusor overactivity
OT  - Hyperactivite detrusorienne
OT  - Hyperactivite vesicale
OT  - Nerve Growth Factor (NGF)
OT  - Overactive bladder
OT  - Urinaire
OT  - Urinary
OT  - Urodynamics
OT  - Urodynamique
EDAT- 2014/12/09 06:00
MHDA- 2015/12/29 06:00
CRDT- 2014/12/09 06:00
PHST- 2014/10/15 00:00 [received]
PHST- 2014/11/07 00:00 [revised]
PHST- 2014/11/10 00:00 [accepted]
PHST- 2014/12/09 06:00 [entrez]
PHST- 2014/12/09 06:00 [pubmed]
PHST- 2015/12/29 06:00 [medline]
AID - S1166-7087(14)00659-9 [pii]
AID - 10.1016/j.purol.2014.11.004 [doi]
PST - ppublish
SO  - Prog Urol. 2015 Mar;25(4):188-99. doi: 10.1016/j.purol.2014.11.004. Epub 2014 Nov 
      18.