PMID- 25484348
OWN - NLM
STAT- MEDLINE
DCOM- 20150803
LR  - 20191210
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 975
DP  - 2015 Jan 15
TI  - Ultrasound assisted microextraction-nano material solid phase dispersion for 
      extraction and determination of thymol and carvacrol in pharmaceutical samples: 
      experimental design methodology.
PG  - 34-9
LID - S1570-0232(14)00676-X [pii]
LID - 10.1016/j.jchromb.2014.10.035 [doi]
AB  - In the present study, for the first time, a new extraction method based on 
      "ultrasound assisted microextraction-nanomaterial solid phase dispersion 
      (UAME-NMSPD)" was developed to preconcentrate the low quantity of thymol and 
      carvacrol in pharmaceutical samples prior to their HPLC-UV 
      separation/determination. The analytes were accumulated on nickel sulfide 
      nanomaterial loaded on activated carbon (NiS-NP-AC) that with more detail 
      identified by XRD, FESEM and UV-vis technique. Central composite design (CCD) 
      combined with desirability function (DF) was used to search for optimum 
      operational conditions. Working under optimum conditions specified as: 10 min 
      ultrasonic time, pH 3, 0.011 g of adsorbent and 600 muL extraction solvent) permit 
      achievement of high and reasonable linear range over 0.005-2.0 mug mL(-1) 
      (r(2)>0.9993) with LOD of thymol and carvacrol as 0.23 and 0.21 mug L(-1), 
      respectively. The relative standard deviations (RSDs) were less than 4.93% (n=3).
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Roosta, Mostafa
AU  - Roosta M
AD  - Chemistry Department, Yasouj University, Yasouj 75918-74831, Iran.
FAU - Ghaedi, Mehrorang
AU  - Ghaedi M
AD  - Chemistry Department, Yasouj University, Yasouj 75918-74831, Iran. Electronic 
      address: m_ghaedi@mail.yu.ac.ir.
FAU - Daneshfar, Ali
AU  - Daneshfar A
AD  - Department of Chemistry, University of Ilam, Ilam 65315-516, Iran.
FAU - Sahraei, Reza
AU  - Sahraei R
AD  - Department of Chemistry, University of Ilam, Ilam 65315-516, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141103
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Cymenes)
RN  - 0 (Monoterpenes)
RN  - 0 (Pharmaceutical Preparations)
RN  - 16291-96-6 (Charcoal)
RN  - 3J50XA376E (Thymol)
RN  - 7OV03QG267 (Nickel)
RN  - 9B1J4V995Q (carvacrol)
RN  - I6929D52YQ (nickel sulfide)
SB  - IM
MH  - Anti-Infective Agents/*isolation & purification
MH  - Charcoal/chemistry
MH  - Chromatography, High Pressure Liquid
MH  - Cymenes
MH  - Equipment Design
MH  - Monoterpenes/*isolation & purification
MH  - Nanostructures/chemistry
MH  - Nickel/chemistry
MH  - Pharmaceutical Preparations/chemistry
MH  - Solid Phase Microextraction/*instrumentation
MH  - Thymol/*isolation & purification
MH  - Ultrasonics/*instrumentation
OTO - NOTNLM
OT  - Central composite design
OT  - Nano material
OT  - Response surface methodology
OT  - Solid phase dispersion
OT  - Ultrasound assisted microextraction
EDAT- 2014/12/09 06:00
MHDA- 2015/08/04 06:00
CRDT- 2014/12/09 06:00
PHST- 2014/06/17 00:00 [received]
PHST- 2014/10/19 00:00 [revised]
PHST- 2014/10/25 00:00 [accepted]
PHST- 2014/12/09 06:00 [entrez]
PHST- 2014/12/09 06:00 [pubmed]
PHST- 2015/08/04 06:00 [medline]
AID - S1570-0232(14)00676-X [pii]
AID - 10.1016/j.jchromb.2014.10.035 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 15;975:34-9. doi: 
      10.1016/j.jchromb.2014.10.035. Epub 2014 Nov 3.