PMID- 25484556
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141208
LR  - 20200930
IS  - 1061-1711 (Print)
IS  - 1615-5939 (Electronic)
IS  - 1061-1711 (Linking)
VI  - 23
IP  - 4
DP  - 2014 Dec
TI  - Catheter-Directed Thrombolysis Along with Mechanical Thromboaspiration versus 
      Anticoagulation Alone in the Management of Lower Limb Deep Venous Thrombosis-A 
      Comparative Study.
PG  - 247-54
LID - 10.1055/s-0034-1382157 [doi]
AB  - Catheter-directed thrombolysis (CDT) with assisted mechanical thrombolysis is now 
      considered as the standard of medical care for deep vein thrombosis (DVT). The 
      study was conducted to describe the immediate and long-term (6 months) safety and 
      effectiveness of CDT in patient with lower limb DVT compared with the routine 
      anticoagulation alone. All 12 to 85 years old patients with recent (0-8 weeks) 
      DVT were included. In CDT group, thrombus was aspirated mechanically and 
      streptokinase (STK) was given along with unfractionated heparin (UFH). After 6 
      months, deep venous patency and postthrombotic syndrome (PTS) was assessed by 
      using duplex ultrasound and Villalta scale, respectively. Among 51 patients with 
      completed data, 25 patients were allocated additional CDT given for a mean 
      duration of 108 +/- 32 hours and 26 patients were allocated standard treatment 
      alone. Grade III (complete) lysis was achieved in 37% patients and grade II 
      (50-90%) lysis in 63% of patients. Patients with partial lysis underwent 
      percutaneous transluminal angioplasty and/or venous stenting. After 6 months, 
      iliofemoral patency was found in 20 (80%) in the CDT group versus 7 (23%) in 
      anticoagulation alone group (p < 0.01). PTS was seen in 5 (20%) in the CDT group 
      versus 19 (77%) in anticoagulation alone group (p < 0.01). We conclude that CDT 
      and conventional manual aspiration thrombectomy are an effective treatment for 
      lower extremity DVT. STK infusion can be safely given up to 6 days. As addition 
      of UFH can cause thrombocytopenia, so daily monitoring of complete blood counts 
      is needed during CDT.
FAU - Srinivas, B C
AU  - Srinivas BC
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bangalore, Karnataka, India.
FAU - Patra, Soumya
AU  - Patra S
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bangalore, Karnataka, India.
FAU - Nagesh, C M
AU  - Nagesh CM
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bangalore, Karnataka, India.
FAU - Reddy, Babu
AU  - Reddy B
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bangalore, Karnataka, India.
FAU - Manjunath, C N
AU  - Manjunath CN
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bangalore, Karnataka, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Angiol
JT  - The International journal of angiology : official publication of the 
      International College of Angiology, Inc
JID - 9504821
PMC - PMC4244239
OTO - NOTNLM
OT  - catheter-directed thrombolysis
OT  - deep vein thrombosis
OT  - iliofemoral
OT  - postthrombotic syndrome
OT  - streptokinase
COIS- Conflict of Interest None.
EDAT- 2014/12/09 06:00
MHDA- 2014/12/09 06:01
PMCR- 2015/12/01
CRDT- 2014/12/09 06:00
PHST- 2014/12/09 06:00 [entrez]
PHST- 2014/12/09 06:00 [pubmed]
PHST- 2014/12/09 06:01 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 140021 [pii]
AID - 10.1055/s-0034-1382157 [doi]
PST - ppublish
SO  - Int J Angiol. 2014 Dec;23(4):247-54. doi: 10.1055/s-0034-1382157.