PMID- 25484590
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141208
LR  - 20240322
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 10
DP  - 2014
TI  - Absent activation in medial prefrontal cortex and temporoparietal junction but 
      not superior temporal sulcus during the perception of biological motion in 
      schizophrenia: a functional MRI study.
PG  - 2221-30
LID - 10.2147/NDT.S70074 [doi]
AB  - BACKGROUND: Patients with schizophrenia show disturbances in both visual 
      perception and social cognition. Perception of biological motion (BM) is a 
      higher-level visual process, and is known to be associated with social cognition. 
      BM induces activation in the "social brain network", including the superior 
      temporal sulcus (STS). Although deficits in the detection of BM and atypical 
      activation in the STS have been reported in patients with schizophrenia, it 
      remains unclear whether other nodes of the "social brain network" are also 
      atypical in patients with schizophrenia. PURPOSE: We aimed to explore whether 
      brain regions other than STS were involved during BM perception in patients with 
      schizophrenia, using functional magnetic resonance imaging (fMRI). METHODS AND 
      PATIENTS: Seventeen patients with schizophrenia, and 17 age- and sex- matched 
      healthy controls, underwent fMRI scanning during a one-back visual task, 
      containing three experimental conditions: (1) BM, (2) scrambled motion (SM), and 
      (3) static condition. We used one-sample t-tests to examine neural responses 
      selective to BM versus SM within each group, and two-sample t-tests to directly 
      compare neural patterns to BM versus SM in schizophrenics versus controls. 
      RESULTS: We found significant activation in the STS region when BM was contrasted 
      with SM in both groups, with no significant difference between groups. On the 
      contrary, significant activation in the medial prefrontal cortex (MPFC) and 
      bilateral temporoparietal junction (TPJ) was found only in the control group. 
      When we directly compared the two groups, the healthy controls showed significant 
      greater activation in left MPFC and TPJ to BM versus SM than patients with 
      schizophrenia. CONCLUSION: Our findings suggest that patients with schizophrenia 
      show normal activation to biologically and socially relevant motion stimuli in 
      the STS, but atypical activation in other regions of the social brain network, 
      specifically MPFC and TPJ. Moreover, these results were not due to atypical 
      processing of motion, suggesting that patients with schizophrenia lack in the 
      recruitment of neural circuits needed for the visual perception of social 
      cognition.
FAU - Hashimoto, Naoki
AU  - Hashimoto N
AD  - Department of Psychiatry, Graduate School of Medicine, Hokkaido University, 
      Sapporo, Japan ; Child and Adolescent Psychiatry, Department of Psychiatry, 
      University of California, San Francisco, CA, USA.
FAU - Toyomaki, Atsuhito
AU  - Toyomaki A
AD  - Department of Psychiatry, Graduate School of Medicine, Hokkaido University, 
      Sapporo, Japan.
FAU - Hirai, Masahiro
AU  - Hirai M
AD  - Center for Development of Advanced Medical Technology, Jichi Medical University, 
      Yakushiji, Shimotsuke, Tochigi, Japan.
FAU - Miyamoto, Tamaki
AU  - Miyamoto T
AD  - Department of Psychiatry, Graduate School of Medicine, Hokkaido University, 
      Sapporo, Japan.
FAU - Narita, Hisashi
AU  - Narita H
AD  - Department of Psychiatry, Graduate School of Medicine, Hokkaido University, 
      Sapporo, Japan.
FAU - Okubo, Ryo
AU  - Okubo R
AD  - Department of Psychiatry, Graduate School of Medicine, Hokkaido University, 
      Sapporo, Japan.
FAU - Kusumi, Ichiro
AU  - Kusumi I
AD  - Department of Psychiatry, Graduate School of Medicine, Hokkaido University, 
      Sapporo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20141117
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC4240192
OTO - NOTNLM
OT  - cognitive processing
OT  - mentalizing
OT  - social brain network
OT  - social cognition
OT  - theory of mind
EDAT- 2014/12/09 06:00
MHDA- 2014/12/09 06:01
PMCR- 2014/11/17
CRDT- 2014/12/09 06:00
PHST- 2014/12/09 06:00 [entrez]
PHST- 2014/12/09 06:00 [pubmed]
PHST- 2014/12/09 06:01 [medline]
PHST- 2014/11/17 00:00 [pmc-release]
AID - ndt-10-2221 [pii]
AID - 10.2147/NDT.S70074 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2014 Nov 17;10:2221-30. doi: 10.2147/NDT.S70074. 
      eCollection 2014.