PMID- 25484893 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 1674-7984 (Print) IS - 1674-7992 (Electronic) IS - 1674-7984 (Linking) VI - 9 IP - 3 DP - 2014 Jun TI - Neurotrophin signaling and visceral hypersensitivity. PG - 216-224 AB - Neurotrophin family are traditionally recognized for their nerve growth promoting function and are recently identified as crucial factors in regulating neuronal activity in the central and peripheral nervous systems. The family members including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) are reported to have distinct roles in the development and maintenance of sensory phenotypes in normal states and in the modulation of sensory activity in disease. This paper highlights receptor tyrosine kinase (Trk) -mediated signal transduction by which neurotrophins regulate neuronal activity in the visceral sensory reflex pathways with emphasis on the distinct roles of NGF and BDNF signaling in physiologic and pathophysiological processes. Viscero-visceral cross-organ sensitization exists widely in human diseases. The role of neurotrophins in mediating neural cross talk and interaction in primary afferent neurons in the dorsal root ganglia (DRG) and neurotrophin signal transduction in the context of cross-organ sensitization are also discussed. FAU - Qiao, Li-Ya AU - Qiao LY AD - Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA. LA - eng GR - R01 DK077917/DK/NIDDK NIH HHS/United States PT - Journal Article PL - China TA - Front Biol (Beijing) JT - Frontiers in biology JID - 101541748 PMC - PMC4254660 MID - NIHMS602758 OTO - NOTNLM OT - cross-sensitization OT - neurotrophin OT - signal transduction OT - visceral hypersensitivity COIS- Compliance with ethics guidelines Li-Ya Qiao declares that she has no conflict of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant insitutional review board or ethics committee. EDAT- 2014/12/09 06:00 MHDA- 2014/12/09 06:01 PMCR- 2014/12/03 CRDT- 2014/12/09 06:00 PHST- 2014/12/09 06:00 [entrez] PHST- 2014/12/09 06:00 [pubmed] PHST- 2014/12/09 06:01 [medline] PHST- 2014/12/03 00:00 [pmc-release] AID - 10.1007/s11515-014-1304-4 [doi] PST - ppublish SO - Front Biol (Beijing). 2014 Jun;9(3):216-224. doi: 10.1007/s11515-014-1304-4.