PMID- 25485088
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141208
LR  - 20200929
IS  - 2045-3701 (Print)
IS  - 2045-3701 (Electronic)
IS  - 2045-3701 (Linking)
VI  - 4
IP  - 1
DP  - 2014
TI  - Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease 
      children with coronary artery aneurysms.
PG  - 67
LID - 10.1186/2045-3701-4-67 [doi]
LID - 67
AB  - BACKGROUND: Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, 
      may develop coronary artery aneurysm (CAA) as a complication. To investigate the 
      role of glutamate receptors in KD and its CAA development, we performed genetic 
      association studies. METHODS AND RESULTS: We examined the whole family of 
      glutamate receptors by genetic association studies in a Taiwanese cohort of 262 
      KD patients. We identified glutamate receptor ionotropic, kainate 1 (GRIK1) as a 
      novel susceptibility locus associated with CAA formation in KD. Statistically 
      significant differences were noted for factors like fever duration, 1st 
      Intravenous immunoglobulin (IVIG) used time (number of days after the first day 
      of fever) and the GRIK1 (rs466013, rs425507, and rs38700) genetic variants. This 
      significant association persisted even after using multivariate regression 
      analysis (Full model: for rs466013: odds ratio =2.12; 95% CI =1.22-3.65; for 
      rs425507: odds ratio =2.16; 95% CI =1.26-3.76; for rs388700: odds ratio =2.16; 
      95% CI =1.26-3.76). CONCLUSIONS: We demonstrated that GRIK1 polymorphisms are 
      associated CAA formation in KD, even when adjusted for fever duration and IVIG 
      used time, and may also serve as a genetic marker for the CAA formation in KD.
FAU - Lin, Ying-Ju
AU  - Lin YJ
AD  - Department of Medical Research, China Medical University Hospital, Taichung, 
      Taiwan ; School of Chinese Medicine, China Medical University, Taichung, Taiwan.
FAU - Chang, Jeng-Sheng
AU  - Chang JS
AD  - Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan.
FAU - Liu, Xiang
AU  - Liu X
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland USA.
FAU - Tsang, Hsinyi
AU  - Tsang H
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland USA.
FAU - Lin, Ting-Hsu
AU  - Lin TH
AD  - Department of Medical Research, China Medical University Hospital, Taichung, 
      Taiwan.
FAU - Liao, Chiu-Chu
AU  - Liao CC
AD  - Department of Medical Research, China Medical University Hospital, Taichung, 
      Taiwan.
FAU - Huang, Shao-Mei
AU  - Huang SM
AD  - Department of Medical Research, China Medical University Hospital, Taichung, 
      Taiwan.
FAU - Chien, Wen-Kuei
AU  - Chien WK
AD  - Biostatistics Center, China Medical University, Taichung, Taiwan ; Biostatistics 
      Center and School of Public Health, Taipei Medical University, Taipei, Taiwan.
FAU - Chen, Jin-Hua
AU  - Chen JH
AD  - Biostatistics Center, China Medical University, Taichung, Taiwan ; Biostatistics 
      Center and School of Public Health, Taipei Medical University, Taipei, Taiwan.
FAU - Wu, Jer-Yuarn
AU  - Wu JY
AD  - School of Chinese Medicine, China Medical University, Taichung, Taiwan ; 
      Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
FAU - Chen, Chien-Hsiun
AU  - Chen CH
AD  - School of Chinese Medicine, China Medical University, Taichung, Taiwan ; 
      Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
FAU - Chang, Li-Ching
AU  - Chang LC
AD  - Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
FAU - Lin, Cheng-Wen
AU  - Lin CW
AD  - Department of Medical Laboratory Science and Biotechnology, China Medical 
      University, Taichung, Taiwan.
FAU - Ho, Tsung-Jung
AU  - Ho TJ
AD  - School of Chinese Medicine, China Medical University, Taichung, Taiwan ; Division 
      of Chinese Medicine, China Medical University Beigang Hospital, Yunlin County, 
      Taiwan ; Division of Chinese Medicine, Tainan Municipal An-Nan Hospital -China 
      Medical University, Tainan, Taiwan.
FAU - Tsai, Fuu-Jen
AU  - Tsai FJ
AD  - Department of Medical Research, China Medical University Hospital, Taichung, 
      Taiwan ; School of Chinese Medicine, China Medical University, Taichung, Taiwan ; 
      Asia University, Taichung, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20141119
PL  - England
TA  - Cell Biosci
JT  - Cell & bioscience
JID - 101561195
PMC - PMC4258047
OTO - NOTNLM
OT  - CAA
OT  - GRIK1
OT  - KD
OT  - Single nucleotide polymorphism
EDAT- 2014/12/09 06:00
MHDA- 2014/12/09 06:01
PMCR- 2014/11/19
CRDT- 2014/12/09 06:00
PHST- 2014/02/07 00:00 [received]
PHST- 2014/10/20 00:00 [accepted]
PHST- 2014/12/09 06:00 [entrez]
PHST- 2014/12/09 06:00 [pubmed]
PHST- 2014/12/09 06:01 [medline]
PHST- 2014/11/19 00:00 [pmc-release]
AID - 193 [pii]
AID - 10.1186/2045-3701-4-67 [doi]
PST - epublish
SO  - Cell Biosci. 2014 Nov 19;4(1):67. doi: 10.1186/2045-3701-4-67. eCollection 2014.