PMID- 25485756
OWN - NLM
STAT- MEDLINE
DCOM- 20150306
LR  - 20220129
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 18
IP  - 1
DP  - 2015 Jan
TI  - Early depolarizing GABA controls critical-period plasticity in the rat visual 
      cortex.
PG  - 87-96
LID - 10.1038/nn.3890 [doi]
AB  - Hyperpolarizing and inhibitory GABA regulates critical periods for plasticity in 
      sensory cortices. Here we examine the role of early, depolarizing GABA in the 
      control of plasticity mechanisms. We report that brief interference with 
      depolarizing GABA during early development prolonged critical-period plasticity 
      in visual cortical circuits without affecting the overall development of the 
      visual system. The effects on plasticity were accompanied by dampened inhibitory 
      neurotransmission, downregulation of brain-derived neurotrophic factor (BDNF) 
      expression and reduced density of extracellular matrix perineuronal nets. Early 
      interference with depolarizing GABA decreased perinatal BDNF signaling, and a 
      pharmacological increase of BDNF signaling during GABA interference rescued the 
      effects on plasticity and its regulators later in life. We conclude that 
      depolarizing GABA exerts a long-lasting, selective modulation of plasticity of 
      cortical circuits by a strong crosstalk with BDNF.
FAU - Deidda, Gabriele
AU  - Deidda G
AD  - Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, 
      Genova, Italy.
FAU - Allegra, Manuela
AU  - Allegra M
AD  - 1] Scuola Normale Superiore, Pisa, Italy. [2] CNR Neuroscience Institute, Pisa, 
      Italy.
FAU - Cerri, Chiara
AU  - Cerri C
AD  - CNR Neuroscience Institute, Pisa, Italy.
FAU - Naskar, Shovan
AU  - Naskar S
AD  - Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, 
      Genova, Italy.
FAU - Bony, Guillaume
AU  - Bony G
AD  - Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, 
      Genova, Italy.
FAU - Zunino, Giulia
AU  - Zunino G
AD  - Laboratory of Molecular Neuropathology, Centre for Integrative Biology (CIBIO), 
      University of Trento, Trento, Italy.
FAU - Bozzi, Yuri
AU  - Bozzi Y
AD  - 1] CNR Neuroscience Institute, Pisa, Italy. [2] Laboratory of Molecular 
      Neuropathology, Centre for Integrative Biology (CIBIO), University of Trento, 
      Trento, Italy.
FAU - Caleo, Matteo
AU  - Caleo M
AD  - CNR Neuroscience Institute, Pisa, Italy.
FAU - Cancedda, Laura
AU  - Cancedda L
AD  - Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, 
      Genova, Italy.
LA  - eng
GR  - GGP10135/TI_/Telethon/Italy
GR  - GGP13187/TI_/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141208
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Diuretics)
RN  - 0 (GABA Antagonists)
RN  - 0Y2S3XUQ5H (Bumetanide)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Bumetanide/pharmacology
MH  - Contrast Sensitivity/drug effects/physiology
MH  - *Critical Period, Psychological
MH  - Diuretics/pharmacology
MH  - Evoked Potentials, Visual/drug effects/physiology
MH  - Female
MH  - GABA Antagonists/pharmacology
MH  - Male
MH  - Maze Learning
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Visual Cortex/drug effects/growth & development/*physiology
MH  - gamma-Aminobutyric Acid/*physiology
PMC - PMC4338533
MID - EMS60901
OID - NLM: EMS60901
EDAT- 2014/12/09 06:00
MHDA- 2015/03/07 06:00
PMCR- 2015/07/01
CRDT- 2014/12/09 06:00
PHST- 2014/09/23 00:00 [received]
PHST- 2014/11/03 00:00 [accepted]
PHST- 2014/12/09 06:00 [entrez]
PHST- 2014/12/09 06:00 [pubmed]
PHST- 2015/03/07 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - nn.3890 [pii]
AID - 10.1038/nn.3890 [doi]
PST - ppublish
SO  - Nat Neurosci. 2015 Jan;18(1):87-96. doi: 10.1038/nn.3890. Epub 2014 Dec 8.