PMID- 25486513
OWN - NLM
STAT- MEDLINE
DCOM- 20151015
LR  - 20150131
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 401
DP  - 2015 Feb 5
TI  - Neonatal exposure to low doses of endosulfan induces implantation failure and 
      disrupts uterine functional differentiation at the pre-implantation period in 
      rats.
PG  - 248-59
LID - S0303-7207(14)00394-3 [pii]
LID - 10.1016/j.mce.2014.11.028 [doi]
AB  - We investigated whether neonatal exposure to low doses of endosulfan affects 
      fertility and uterine functional differentiation at pre-implantation in rats. 
      Newborn female rats received the vehicle, 0.2 microg/kg/d of diethylstilbestrol 
      (DES), 6 microg/kg/d of endosulfan (Endo6) or 600 microg/kg/d of endosulfan (Endo600) on 
      postnatal days (PND) 1, 3, 5, and 7. On PND90, the rats were mated to evaluate 
      their reproductive performance on gestational day (GD) 19 and their ovarian 
      steroid serum levels, endometrial proliferation and implantation-associated 
      proteins on GD5. DES and endosulfan decreased the pregnancy rate and the number 
      of implantation sites. On GD5, DES and endosulfan did not change the serum levels 
      of 17beta-estradiol (E2) and progesterone (P); the endometrial proliferation 
      decreased, which was associated with silencing of Hoxa10 in the Endo600-treated 
      rats. Both doses of endosulfan increased the progesterone receptor (PR) 
      expression, whereas the higher dose led additionally to an increase in estrogen 
      receptor alpha (ERalpha). In the Endo600-treated rats, the down-regulation of Hoxa10 
      was associated with a deregulation of the steroid receptor coregulators. 
      Alterations in endometrial proliferation and the endocrine pathway of 
      Hoxa10/steroid receptors/coregulators might be the mechanism of 
      endosulfan-induced implantation failure.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Milesi, Maria M
AU  - Milesi MM
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Alarcon, Ramiro
AU  - Alarcon R
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Ramos, Jorge G
AU  - Ramos JG
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Munoz-de-Toro, Monica
AU  - Munoz-de-Toro M
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Luque, Enrique H
AU  - Luque EH
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Varayoud, Jorgelina
AU  - Varayoud J
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina. Electronic 
      address: varayoud@fbcb.unl.edu.ar.
LA  - eng
PT  - Journal Article
DEP - 20141205
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Carcinogens)
RN  - 0 (Insecticides)
RN  - 0 (Steroids)
RN  - 731DCA35BT (Diethylstilbestrol)
RN  - OKA6A6ZD4K (Endosulfan)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Carcinogens/administration & dosage/toxicity
MH  - Cell Proliferation/drug effects
MH  - Diethylstilbestrol/administration & dosage/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Embryo Implantation/*drug effects
MH  - Endosulfan/*administration & dosage/toxicity
MH  - Female
MH  - Fertility/*drug effects
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Insecticides/*administration & dosage/toxicity
MH  - Pregnancy
MH  - Pregnancy Rate
MH  - Rats
MH  - Rats, Wistar
MH  - Steroids/blood
MH  - Uterus/*drug effects/growth & development
OTO - NOTNLM
OT  - Endosulfan
OT  - Estrogen receptor alpha
OT  - Hoxa10
OT  - Implantation
OT  - Progesterone receptor
OT  - Uterus
EDAT- 2014/12/09 06:00
MHDA- 2015/10/16 06:00
CRDT- 2014/12/09 06:00
PHST- 2014/07/12 00:00 [received]
PHST- 2014/11/26 00:00 [revised]
PHST- 2014/11/28 00:00 [accepted]
PHST- 2014/12/09 06:00 [entrez]
PHST- 2014/12/09 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - S0303-7207(14)00394-3 [pii]
AID - 10.1016/j.mce.2014.11.028 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2015 Feb 5;401:248-59. doi: 10.1016/j.mce.2014.11.028. Epub 
      2014 Dec 5.