PMID- 25486541
OWN - NLM
STAT- MEDLINE
DCOM- 20150417
LR  - 20150922
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 3
DP  - 2015 Mar
TI  - Risk factors predictive of endogenous endophthalmitis among hospitalized patients 
      with hematogenous infections in the United States.
PG  - 498-504
LID - S0002-9394(14)00777-6 [pii]
LID - 10.1016/j.ajo.2014.11.032 [doi]
AB  - PURPOSE: To identify potential risk factors associated with endogenous 
      endophthalmitis among hospitalized patients with hematogenous infections. DESIGN: 
      Retrospective cross-sectional study. METHODS: MarketScan Commercial Claims and 
      Encounters, and Medicare Supplemental and Coordination of Benefit inpatient 
      databases from the years 2007-2011 were obtained. Utilizing ICD-9 codes, logistic 
      regression was used to identify potential predictors/comorbidities for developing 
      endophthalmitis in patients with hematogenous infections. RESULTS: Among 
      inpatients with hematogenous infections, the overall incidence rate of presumed 
      endogenous endophthalmitis was 0.05%-0.4% among patients with fungemia and 0.04% 
      among patients with bacteremia. Comorbid human immunodeficiency virus 
      infection/acquired immunodeficiency syndrome (HIV/AIDS) (OR = 4.27; CI, 
      1.55-11.8; P = .005), tuberculosis (OR = 8.5; CI, 1.2-61.5; P = .03), 
      endocarditis (OR = 8.3; CI, 4.9-13.9; P < .0001), bacterial meningitis (OR = 3.8; 
      CI, 1.2-12.0; P = .023), fungal meningitis (OR = 59.1; CI, 14.1-247.8; P < 
      .0001), internal organ abscess (OR = 2.9; CI, 1.2-6.4; P = .02), 
      lymphoma/leukemia (OR = 2.9; CI, 1.6-5.3; P < .0001), skin abscess/cellulitis (OR 
      = 1.75; CI, 1.1-2.8; P = .02), pyogenic arthritis (OR = 4.2; CI, 1.8-9.6; P = 
      .001), diabetes with ophthalmic manifestations (OR = 7.0; CI, 1.7-28.3; P = 
      .006), and urinary tract infection (OR = 0.04; CI, 0.3-0.9; P = .023) were each 
      significantly associated with a diagnosis of endogenous endophthalmitis. Patients 
      aged 0-17 years (OR = 2.61; CI, 1.2-5.7; P = .02), 45-54 years (OR = 3.4; CI, 
      2.0-5.4; P < .0001), and 55-64 years (OR = 2.9; CI, 1.8-4.8; P < .0001); those 
      having length of stay of 3-10 days (OR = 1.9; CI, 1.1-3.3; P = .01), 11-30 days 
      (OR = 3.1; CI, 1.8-5.5; P < .0001), and 31+ days (OR = 5.3; CI, 2.7-10.4; P < 
      .0001); and those with intensive care unit/neonatal intensive care unit 
      (ICU/NICU) admissions (OR = 1.5; CI, 1.4-1.6; P < .0001) were all more likely to 
      be diagnosed with endogenous endophthalmitis. CONCLUSIONS: Endogenous 
      endophthalmitis is rare among hospitalized patients in the United States. Among 
      patients with hematogenous infections, odds of endogenous endophthalmitis were 
      higher for children and middle-aged patients, and for patients with endocarditis, 
      bacterial meningitis, lymphoma/leukemia, HIV/AIDS, internal organ abscess, 
      diabetes with ophthalmic manifestations, skin cellulitis/abscess, pyogenic 
      arthritis, tuberculosis, longer hospital stays, and/or ICU/NICU admission.
CI  - Published by Elsevier Inc.
FAU - Vaziri, Kamyar
AU  - Vaziri K
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 
      Miller School of Medicine, Palm Beach Gardens, Florida.
FAU - Pershing, Suzann
AU  - Pershing S
AD  - Department of Ophthalmology, Byers Eye Institute, Stanford University School of 
      Medicine, Palo Alto, California; Veterans Affairs Palo Alto Health Care System, 
      Palo Alto, Calfornia. Electronic address: pershing@stanford.edu.
FAU - Albini, Thomas A
AU  - Albini TA
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 
      Miller School of Medicine, Palm Beach Gardens, Florida.
FAU - Moshfeghi, Darius M
AU  - Moshfeghi DM
AD  - Department of Ophthalmology, Byers Eye Institute, Stanford University School of 
      Medicine, Palo Alto, California.
FAU - Moshfeghi, Andrew A
AU  - Moshfeghi AA
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 
      Miller School of Medicine, Palm Beach Gardens, Florida; Retina Associates of 
      Kentucky, Lexington, Kentucky.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141206
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
CIN - Am J Ophthalmol. 2015 Aug;160(2):391-2. PMID: 26187877
CIN - Am J Ophthalmol. 2015 Aug;160(2):392. PMID: 26187878
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bacteremia/diagnosis/*epidemiology/microbiology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Databases, Factual/statistics & numerical data
MH  - Endophthalmitis/diagnosis/*epidemiology/microbiology
MH  - Eye Infections, Bacterial/diagnosis/*epidemiology/microbiology
MH  - Eye Infections, Fungal/diagnosis/*epidemiology/microbiology
MH  - Female
MH  - Fungemia/diagnosis/*epidemiology/microbiology
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - United States/epidemiology
EDAT- 2014/12/09 06:00
MHDA- 2015/04/18 06:00
CRDT- 2014/12/09 06:00
PHST- 2014/07/30 00:00 [received]
PHST- 2014/11/20 00:00 [revised]
PHST- 2014/11/21 00:00 [accepted]
PHST- 2014/12/09 06:00 [entrez]
PHST- 2014/12/09 06:00 [pubmed]
PHST- 2015/04/18 06:00 [medline]
AID - S0002-9394(14)00777-6 [pii]
AID - 10.1016/j.ajo.2014.11.032 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Mar;159(3):498-504. doi: 10.1016/j.ajo.2014.11.032. Epub 
      2014 Dec 6.