PMID- 2548661
OWN - NLM
STAT- MEDLINE
DCOM- 19890922
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 491
IP  - 1
DP  - 1989 Jul 3
TI  - Two distinct quisqualate receptor systems are present on striatal neurons.
PG  - 189-93
AB  - At concentrations at which it did not alter spontaneous release, quisqualate 
      (QUIS) induced a dose-dependent (EC50, 0.5 microM) potentiation of KCl- or 
      veratrine-evoked release of [3H]GABA from striatal neurons in primary culture. 
      QUIS potentiation of KCl-evoked [3H]GABA release was mimicked by the selective 
      agonist alpha-amino-3-hydroxy-5-methylisoxazole-propionic acid (AMPA), glutamate 
      and kainate, and was blocked by kynurenic acid and gamma-D-glutamylglycine. QUIS 
      also induced a dose-dependent (EC50, 0.2 microM) augmentation of [3H]inositol 
      monophosphate production in striatal neurons. This action of QUIS was mimicked by 
      glutamate, but not by AMPA nor by kainate. Furthermore, none of the antagonists 
      tested (kynurenic acid, gamma-D-glutamylglycine, glutamic acid diethyl ester, and 
      4-aminophosphonobutanoic acid) could block QUIS-induced elevations in 
      [3H]inositol monophosphate production. The results of the present study suggest 
      that two QUIS receptor systems, distinguished on the basis of their 
      pharmacological properties, may subserve specific roles in the regulation of 
      striatal neuron function by excitatory amino acids.
FAU - Weiss, S
AU  - Weiss S
AD  - Department of Pathology, University of Calgary Faculty of Medicine, Alta. Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Inositol Phosphates)
RN  - 0 (Oxadiazoles)
RN  - 0 (Oxazoles)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 2552-55-8 (Ibotenic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 77521-29-0 (alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid)
RN  - 8OC22C1B99 (Quisqualic Acid)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Corpus Striatum/cytology/drug effects/*metabolism
MH  - Ibotenic Acid/analogs & derivatives/*pharmacology
MH  - Inositol Phosphates/metabolism
MH  - Mice
MH  - Oxadiazoles/metabolism/*pharmacology
MH  - Oxazoles/*pharmacology
MH  - Quisqualic Acid
MH  - Receptors, AMPA
MH  - Receptors, Neurotransmitter/classification/drug effects/*physiology
MH  - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
MH  - gamma-Aminobutyric Acid/*pharmacokinetics
EDAT- 1989/07/03 00:00
MHDA- 1989/07/03 00:01
CRDT- 1989/07/03 00:00
PHST- 1989/07/03 00:00 [pubmed]
PHST- 1989/07/03 00:01 [medline]
PHST- 1989/07/03 00:00 [entrez]
AID - 0006-8993(89)90104-2 [pii]
AID - 10.1016/0006-8993(89)90104-2 [doi]
PST - ppublish
SO  - Brain Res. 1989 Jul 3;491(1):189-93. doi: 10.1016/0006-8993(89)90104-2.