PMID- 25487935 OWN - NLM STAT- MEDLINE DCOM- 20151006 LR - 20181202 IS - 2284-0729 (Electronic) IS - 1128-3602 (Linking) VI - 18 IP - 21 DP - 2014 TI - Obesity itself does not influence BDNF serum levels in adults. PG - 3246-50 LID - 8023 [pii] AB - OBJECTIVE: In European countries more than 50% of the population are overweight, 30% with obesity. In Poland overweight was present in 41% of men and 28.7% of women (obesity 15.7% and 19.9%). It was examined whether obesity affects serum levels of brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6), which may lead to the consequences of obesity, such as type 2 diabetes, hypertension, and finally the metabolic syndrome. We aimed to examine whether obesity affects the serum levels of BDNF and IL-6. PATIENTS AND METHODS: The study involved 144 people aged 45 to 86 years, 80 subjects with diagnosed obesity and 64 with normal body weight, 65 years old (n = 99). All patients underwent tests of glucose, total cholesterol, HDL, LDL, triglycerides levels, using routine laboratory methods. A test of the concentration of IL-6 and BDNF was carried out. The declared level of physical activity (gymnastics, cycling or walking) was considered. RESULTS: It was shown that in women