PMID- 25488259
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20220408
IS  - 1618-0402 (Electronic)
IS  - 0940-9602 (Linking)
VI  - 198
DP  - 2015 Mar
TI  - Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating 
      olfactory epithelium of Xenopus laevis.
PG  - 41-8
LID - S0940-9602(14)00183-6 [pii]
LID - 10.1016/j.aanat.2014.10.010 [doi]
AB  - Olfactory epithelium has the capability to continuously regenerate olfactory 
      receptor neurons throughout life. Adult neurogenesis results from proliferation 
      and differentiation of neural stem cells, and consequently, olfactory 
      neuroepithelium offers an excellent opportunity to study neural regeneration and 
      the factors involved in the maintenance and regeneration of all their cell types. 
      We analyzed the expression of BDNF in the olfactory system under normal 
      physiological conditions as well as during a massive regeneration induced by 
      chemical destruction of the olfactory epithelium in Xenopus laevis larvae. We 
      described the expression and presence of BDNF in the olfactory epithelium and 
      bulb. In normal physiological conditions, sustentacular (glial) cells and a few 
      scattered basal (stem) cells express BDNF in the olfactory epithelium as well as 
      the granular cells in the olfactory bulb. Moreover, during massive regeneration, 
      we demonstrated a drastic increase in basal cells expressing BDNF as well as an 
      increase in BDNF in the olfactory bulb and nerve. Together these results suggest 
      an important role of BDNF in the maintenance and regeneration of the olfactory 
      system.
CI  - Copyright (c) 2014 Elsevier GmbH. All rights reserved.
FAU - Frontera, Jimena Laura
AU  - Frontera JL
AD  - Instituto de Fisiologia, Biologia Molecular y Neurociencias (IFIBYNE-CONICET), 
      Universidad de Buenos Aires, Buenos Aires, Argentina.
FAU - Cervino, Ailen Soledad
AU  - Cervino AS
AD  - Laboratorio de Biologia del Desarrollo, Departamento de Biodiversidad y Biologia 
      Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos 
      Aires, Buenos Aires, Argentina.
FAU - Jungblut, Lucas David
AU  - Jungblut LD
AD  - Instituto de Fisiologia, Biologia Molecular y Neurociencias (IFIBYNE-CONICET), 
      Universidad de Buenos Aires, Buenos Aires, Argentina; Laboratorio de Biologia del 
      Desarrollo, Departamento de Biodiversidad y Biologia Experimental, Facultad de 
      Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, 
      Argentina.
FAU - Paz, Dante Agustin
AU  - Paz DA
AD  - Instituto de Fisiologia, Biologia Molecular y Neurociencias (IFIBYNE-CONICET), 
      Universidad de Buenos Aires, Buenos Aires, Argentina; Laboratorio de Biologia del 
      Desarrollo, Departamento de Biodiversidad y Biologia Experimental, Facultad de 
      Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, 
      Argentina. Electronic address: dante@bg.fcen.uba.ar.
LA  - eng
PT  - Journal Article
DEP - 20141113
PL  - Germany
TA  - Ann Anat
JT  - Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische 
      Gesellschaft
JID - 100963897
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Nerve Regeneration/physiology
MH  - Neurogenesis/physiology
MH  - Olfactory Bulb/*pathology/*physiopathology
MH  - Olfactory Mucosa/*pathology/*physiopathology
MH  - Xenopus laevis
OTO - NOTNLM
OT  - Neural stem cells
OT  - Neurogenesis
OT  - Neurotrophins
OT  - Olfactory bulb
OT  - Olfactory neurons
OT  - Sustentacular cells
EDAT- 2014/12/10 06:00
MHDA- 2015/11/17 06:00
CRDT- 2014/12/10 06:00
PHST- 2014/09/03 00:00 [received]
PHST- 2014/10/23 00:00 [revised]
PHST- 2014/10/24 00:00 [accepted]
PHST- 2014/12/10 06:00 [entrez]
PHST- 2014/12/10 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
AID - S0940-9602(14)00183-6 [pii]
AID - 10.1016/j.aanat.2014.10.010 [doi]
PST - ppublish
SO  - Ann Anat. 2015 Mar;198:41-8. doi: 10.1016/j.aanat.2014.10.010. Epub 2014 Nov 13.