PMID- 25488807
OWN - NLM
STAT- MEDLINE
DCOM- 20151214
LR  - 20220129
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Linking)
VI  - 26
IP  - 2
DP  - 2015 Feb
TI  - Incident type 2 diabetes and hip fracture risk: a population-based matched cohort 
      study.
PG  - 827-33
LID - 10.1007/s00198-014-2986-9 [doi]
AB  - SUMMARY: There is scarce data on the association between early stages of type 2 
      diabetes and fracture risk. We report a 20% excess risk of hip fracture in the 
      first years following disease onset compared to matched non-diabetic patients. 
      INTRODUCTION: Type 2 diabetes mellitus (T2DM) is a chronic disease that affects 
      several target organs. Data on the association between T2DM and osteoporotic 
      fractures is controversial. We estimated risk of hip fracture in newly diagnosed 
      T2DM patients, compared to matched non-diabetic peers. METHODS: We conducted a 
      population-based parallel cohort study using data from the Sistema d'Informacio 
      per al Desenvolupament de la Investigacio en Atencio Primaria (SIDIAP) database. 
      Participants were all newly diagnosed T2DM patients registered in SIDIAP in 
      2006-2011 (T2DM cohort). Up to two diabetes-free controls were matched to each 
      T2DM participant on age, gender, and primary care practice. Main outcome was 
      incident hip fracture in 2006-2011, ascertained using the tenth edition of the 
      International Classification of Diseases (ICD-10) codes. We used Fine and Gray 
      survival modelling to estimate risk of hip fracture according to T2DM status, 
      accounting for competing risk of death. Multivariate models were adjusted for 
      body mass index, previous fracture, and use of oral corticosteroids. RESULTS: 
      During the study period (median follow-up 2.63 years), 444/58,483 diabetic 
      patients sustained a hip fracture (incidence rate 2.7/1,000 person-years) 
      compared to 776/113,448 matched controls (2.4/1,000). This is equivalent to an 
      unadjusted (age- and gender-matched) subhazard ratio (SHR) 1.11 [0.99-1.24], and 
      adjusted SHR 1.20 [1.06-1.35]. The adjusted SHR for major osteoporotic and any 
      osteoporotic fractures were 0.95 [0.89-1.01] and 0.97 [0.92-1.02]. CONCLUSIONS: 
      Newly diagnosed T2DM patients are at a 20% increased risk of hip fracture even in 
      early stages of disease, but no for all fractures. More data is needed on the 
      causes for an increased fracture risk in T2DM patients as well as on the 
      predictors of osteoporotic fractures among these patients.
FAU - Martinez-Laguna, D
AU  - Martinez-Laguna D
AD  - GREMPAL Research Group, Idiap Jordi Gol Primary Care Research Institute, 
      Universitat Autonoma de Barcelona, Barcelona, Spain.
FAU - Tebe, C
AU  - Tebe C
FAU - Javaid, M K
AU  - Javaid MK
FAU - Nogues, X
AU  - Nogues X
FAU - Arden, N K
AU  - Arden NK
FAU - Cooper, C
AU  - Cooper C
FAU - Diez-Perez, A
AU  - Diez-Perez A
FAU - Prieto-Alhambra, D
AU  - Prieto-Alhambra D
LA  - eng
GR  - MC_U147585827/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_A620_1014/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_12011/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20141209
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation 
      between the European Foundation for Osteoporosis and the National Osteoporosis 
      Foundation of the USA
JID - 9100105
SB  - IM
MH  - Aged
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Female
MH  - Hip Fractures/epidemiology/*etiology
MH  - Humans
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Osteoporotic Fractures/epidemiology/*etiology
MH  - Risk Assessment/methods
MH  - Spain/epidemiology
EDAT- 2014/12/10 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/12/10 06:00
PHST- 2014/07/28 00:00 [received]
PHST- 2014/11/27 00:00 [accepted]
PHST- 2014/12/10 06:00 [entrez]
PHST- 2014/12/10 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1007/s00198-014-2986-9 [doi]
PST - ppublish
SO  - Osteoporos Int. 2015 Feb;26(2):827-33. doi: 10.1007/s00198-014-2986-9. Epub 2014 
      Dec 9.