PMID- 25489602
OWN - NLM
STAT- MEDLINE
DCOM- 20150917
LR  - 20181202
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2014
DP  - 2014
TI  - Tinzaparin provides lower lipid profiles in maintenance hemodialysis patients: a 
      cross-sectional observational study.
PG  - 486781
LID - 10.1155/2014/486781 [doi]
LID - 486781
AB  - As a low-molecular-weight heparin, tinzaparin has effectively been used as an 
      anticoagulant during hemodialysis sessions. However, the impact of different 
      heparin types on dyslipidemia is still controversial. In our study, 434 chronic 
      hemodialysis patients were evaluated. The mean age was 65 +/- 13. Forty-eight 
      patients (11%) and 386 patients (89%) were in the tinzaparin and unfractionated 
      heparin (UFH) groups, respectively. Triglyceride had significant difference 
      between the two groups (P = 0.001) but total cholesterol, HDL, or LDL did not. In 
      the univariate analysis, the triglyceride level was significantly associated with 
      tinzaparin use [beta: -39.9, 95% confidence interval (CI): -76.7 to -3.0], and this 
      association remained following the multivariate analysis (beta: -40.8, 95% CI: -75.1 
      to -6.5). The difference in serum total cholesterol level between tinzaparin and 
      UFH became significant (beta: -13, 95% CI: -24.5 to -1.56) after adjustment in the 
      multivariate analysis. Moreover, in a subgroup analysis, male diabetic patients 
      showed lower serum triglyceride levels with the use of tinzaparin, while older, 
      nondiabetic, male patients showed significant advantages in total cholesterol 
      levels with the use of tinzaparin. Based on our findings, tinzaparin shows a 
      significant association with a lower lipid profile in patients with chronic 
      hemodialysis when compared to UFH.
FAU - Tsai, Ming-Hsien
AU  - Tsai MH
AD  - Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su 
      Memorial Hospital, No. 95 Wen-Chang Road, Shih-Lin District, Taipei 111, Taiwan ; 
      Institute of Epidemiology and Preventive Medicine, College of Public Health, 
      National Taiwan University, No. 17 Hsu Chow Road, Zhongzheng District, Taipei 
      100, Taiwan.
FAU - Fang, Yu-Wei
AU  - Fang YW
AD  - Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su 
      Memorial Hospital, No. 95 Wen-Chang Road, Shih-Lin District, Taipei 111, Taiwan.
FAU - Leu, Jyh-Gang
AU  - Leu JG
AD  - Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su 
      Memorial Hospital, No. 95 Wen-Chang Road, Shih-Lin District, Taipei 111, Taiwan ; 
      Fu-Jen Catholic University School of Medicine, No. 510 Zhongzheng Road, Xinzhuang 
      District, New Taipei City 24205, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20141113
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
RN  - 7UQ7X4Y489 (Tinzaparin)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aged
MH  - Cholesterol/blood
MH  - Cross-Sectional Studies
MH  - Demography
MH  - Female
MH  - Heparin, Low-Molecular-Weight/*pharmacology
MH  - Humans
MH  - Linear Models
MH  - Lipids/*blood
MH  - Male
MH  - Multivariate Analysis
MH  - *Renal Dialysis
MH  - Tinzaparin
MH  - Triglycerides/blood
PMC - PMC4247963
EDAT- 2014/12/10 06:00
MHDA- 2015/09/18 06:00
PMCR- 2014/11/13
CRDT- 2014/12/10 06:00
PHST- 2014/07/13 00:00 [received]
PHST- 2014/10/13 00:00 [revised]
PHST- 2014/10/14 00:00 [accepted]
PHST- 2014/12/10 06:00 [entrez]
PHST- 2014/12/10 06:00 [pubmed]
PHST- 2015/09/18 06:00 [medline]
PHST- 2014/11/13 00:00 [pmc-release]
AID - 10.1155/2014/486781 [doi]
PST - ppublish
SO  - ScientificWorldJournal. 2014;2014:486781. doi: 10.1155/2014/486781. Epub 2014 Nov 
      13.