PMID- 25491769
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20181113
IS  - 2095-0225 (Electronic)
IS  - 2095-0217 (Linking)
VI  - 9
IP  - 1
DP  - 2015 Mar
TI  - Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: 
      perspectives and challenges.
PG  - 20-9
LID - 10.1007/s11684-014-0371-x [doi]
AB  - Ischemic stroke is a focal cerebral insult that often leads to many adverse 
      neurological complications severely affecting the quality of life. The prevalence 
      of stroke is increasing throughout the world, while the efficacy of current 
      pharmacological therapies remains unclear. As a neuroregenerative therapy, the 
      implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown 
      great possibility to restore function after stroke. This review article provides 
      an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With 
      the unique "immunosuppressive and immunoprivilege" property, hUC-MSCs are advised 
      to be an important candidate for allogeneic cell treatment. Nevertheless, most of 
      the treatments are still at primary stage and not clinically feasible at the 
      current time. Several uncertain problems, such as culture conditions, allograft 
      rejection, and potential tumorigenicity, are the choke points in this cellular 
      therapy. More preclinical researches and clinical studies are needed before 
      hUC-MSCs implantation can be used as a routinely applied clinical therapy.
FAU - Li, Yingchen
AU  - Li Y
AD  - Post-Graduate School, Hunan University of Traditional Chinese Medicine, Changsha, 
      410208, China.
FAU - Hu, Guoheng
AU  - Hu G
FAU - Cheng, Qilai
AU  - Cheng Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141209
PL  - China
TA  - Front Med
JT  - Frontiers of medicine
JID - 101549428
SB  - IM
MH  - Brain/*physiology
MH  - Brain Ischemia/*complications
MH  - Cell- and Tissue-Based Therapy
MH  - Cord Blood Stem Cell Transplantation/*methods
MH  - Humans
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Quality of Life
MH  - Recovery of Function
MH  - *Regeneration
MH  - Stroke/etiology/psychology/*therapy
MH  - Treatment Outcome
EDAT- 2014/12/11 06:00
MHDA- 2015/11/17 06:00
CRDT- 2014/12/11 06:00
PHST- 2014/02/24 00:00 [received]
PHST- 2014/08/12 00:00 [accepted]
PHST- 2014/12/11 06:00 [entrez]
PHST- 2014/12/11 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
AID - 10.1007/s11684-014-0371-x [doi]
PST - ppublish
SO  - Front Med. 2015 Mar;9(1):20-9. doi: 10.1007/s11684-014-0371-x. Epub 2014 Dec 9.