PMID- 25494871
OWN - NLM
STAT- MEDLINE
DCOM- 20160622
LR  - 20180816
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 40
IP  - 1
DP  - 2015 Jan
TI  - Fasting and exercise differentially regulate BDNF mRNA expression in human 
      skeletal muscle.
PG  - 96-8
LID - 10.1139/apnm-2014-0290 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) gene expression was measured in human 
      skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in 
      BDNF mRNA was observed following exercise, while fasting upregulated BDNF by  approximately  
      3.5-fold. These changes were dissociated from changes in peroxisome 
      proliferator-activated receptor gamma coactivator 1 alpha (PGC-1alpha) following 
      exercise (+2- to 15-fold) and fasting ( approximately -25%). These results challenge our 
      understanding of the response of BDNF to energetic stress and highlight the 
      importance of future work in this area.
FAU - Walsh, Jeremy J
AU  - Walsh JJ
AD  - School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L 
      3N6, Canada.
FAU - Edgett, Brittany A
AU  - Edgett BA
FAU - Tschakovsky, Michael E
AU  - Tschakovsky ME
FAU - Gurd, Brendon J
AU  - Gurd BJ
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Bicycling
MH  - Brain-Derived Neurotrophic Factor/*agonists/genetics/metabolism
MH  - Cross-Over Studies
MH  - *Exercise
MH  - Fasting/*adverse effects
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - Motor Activity
MH  - Muscle, Skeletal/*metabolism/physiology
MH  - Oxygen Consumption
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Physical Exertion
MH  - Quadriceps Muscle/metabolism/physiology
MH  - RNA, Messenger/*metabolism
MH  - *Stress, Physiological
MH  - Transcription Factors/agonists/genetics/metabolism
MH  - Up-Regulation
MH  - Young Adult
OTO - NOTNLM
OT  - PGC-1alpha
OT  - energetic stress
OT  - exercice par intervalle d'intensite elevee
OT  - high-intensity interval exercise
OT  - stress energetique
EDAT- 2014/12/17 06:00
MHDA- 2016/06/23 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2016/06/23 06:00 [medline]
AID - 10.1139/apnm-2014-0290 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2015 Jan;40(1):96-8. doi: 10.1139/apnm-2014-0290.