PMID- 25496540
OWN - NLM
STAT- MEDLINE
DCOM- 20150813
LR  - 20220318
IS  - 1876-7591 (Electronic)
IS  - 1876-7591 (Linking)
VI  - 7
IP  - 12
DP  - 2014 Dec
TI  - LGE patterns in pulmonary hypertension do not impact overall mortality.
PG  - 1209-17
LID - S1936-878X(14)00853-5 [pii]
LID - 10.1016/j.jcmg.2014.08.014 [doi]
AB  - OBJECTIVES: The goal of this study was to determine the prognostic value of late 
      gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) features in 
      patients with pulmonary hypertension. BACKGROUND: The prognostic significance of 
      LGE in the clinical assessment of patients with pulmonary hypertension remains 
      uncertain. METHODS: Consecutive patients with suspected pulmonary hypertension 
      seen at a specialist pulmonary hypertension referral center who underwent right 
      heart catheterization and CMR with LGE imaging within 48 h were identified. 
      Short-axis late-enhancement imaging was performed using a 3-dimensional gradient 
      spoiled echocardiography sequence on a 1.5-T scanner. Three groups were 
      identified: 1) no late enhancement of the myocardium; 2) late enhancement at the 
      right ventricular insertion points (LGE-IP); and 3) late enhancement involving 
      the right ventricular insertion points and the interventricular septum (LGE-S). 
      RESULTS: Of 194 patients, 162 had pulmonary hypertension. LGE was identified in 
      135 of 162 (83%) patients with pulmonary hypertension, and 47 (29%) of patients 
      demonstrated LGE-S. Patients with LGE-S had significantly higher right 
      ventricular end-diastolic volume index (p = 0.013) and lower mixed venous oxygen 
      saturation (p = 0.045) than patients with LGE-IP alone. The presence of LGE-S 
      (p = 0.022), but not LGE-IP alone, right ventricular end-systolic volume (p = 
      0.045), right ventricular ejection fraction (p = 0.034), mixed venous oxygen 
      saturation (p = 0.021), mean right atrial pressure (0.027), and male sex (p = 
      0.002) predicted mortality. At multivariate analysis, male sex was the only 
      significant predictor of mortality independent of covariate predictors (p = 
      0.027). CONCLUSIONS: The presence of LGE at the right ventricular insertion 
      points is suggestive of the presence of pulmonary hypertension. LGE may also be 
      more extensive, involving the septum; however, after multivariable analysis 
      including other factors associated with pulmonary hypertension, septal LGE was 
      not associated with an increase in overall mortality.
CI  - Copyright (c) 2014 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Swift, Andrew J
AU  - Swift AJ
AD  - Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom; 
      INSIGNEO, Institute for In Silico Medicine, University of Sheffield, United 
      Kingdom. Electronic address: a.j.swift@shef.ac.uk.
FAU - Rajaram, Smitha
AU  - Rajaram S
AD  - Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom.
FAU - Capener, Dave
AU  - Capener D
AD  - Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom.
FAU - Elliot, Charlie
AU  - Elliot C
AD  - Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield 
      Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
FAU - Condliffe, Robin
AU  - Condliffe R
AD  - Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield 
      Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
FAU - Wild, Jim M
AU  - Wild JM
AD  - Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom.
FAU - Kiely, David G
AU  - Kiely DG
AD  - Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield 
      Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
LA  - eng
GR  - BRF-2011-023/DH_/Department of Health/United Kingdom
GR  - NIHR-RP-R3-12-027/DH_/Department of Health/United Kingdom
PT  - Evaluation Study
PT  - Journal Article
DEP - 20141031
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
CIN - JACC Cardiovasc Imaging. 2014 Dec;7(12):1218-20. PMID: 25496541
MH  - Adult
MH  - Aged
MH  - Atrial Function, Right
MH  - Atrial Pressure
MH  - Cardiac Catheterization
MH  - *Contrast Media
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnosis/*mortality/physiopathology
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Organometallic Compounds
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Factors
MH  - Sex Factors
MH  - Stroke Volume
MH  - Ventricular Function, Right
OTO - NOTNLM
OT  - cardiac magnetic resonance
OT  - gadolinium
OT  - idiopathic pulmonary arterial hypertension
OT  - prognosis right ventricle
OT  - pulmonary hypertension
EDAT- 2014/12/17 06:00
MHDA- 2015/08/14 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/03/13 00:00 [received]
PHST- 2014/08/07 00:00 [revised]
PHST- 2014/08/15 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/08/14 06:00 [medline]
AID - S1936-878X(14)00853-5 [pii]
AID - 10.1016/j.jcmg.2014.08.014 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2014 Dec;7(12):1209-17. doi: 10.1016/j.jcmg.2014.08.014. 
      Epub 2014 Oct 31.