PMID- 25497063
OWN - NLM
STAT- MEDLINE
DCOM- 20151021
LR  - 20221207
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 79
IP  - 2
DP  - 2015 Feb
TI  - Histamine skin reactivity increases with body mass index in Korean children.
PG  - 111-4
LID - S0165-5876(14)00610-7 [pii]
LID - 10.1016/j.ijporl.2014.11.012 [doi]
AB  - OBJECTIVE: Histamine skin prick testing is most commonly used to diagnose 
      immunoglobulin E (IgE)-mediated allergic diseases, and histamine reactivity is 
      used as a standardized positive control in the interpretation of a skin prick 
      test. However, reactivity to histamine differs among individuals for reasons that 
      are poorly understood. The present study aimed to evaluate the potential 
      association between body mass index (BMI) and histamine skin reactivity in 
      children. METHODS: A total of 451 children (246 boys, 205 girls) aged 7-8 years 
      were enrolled in this study. The skin prick test was performed with 26 
      aeroallergens commonly found in Korea. Other information was collected, including 
      sex, age, BMI, parental allergy history, and parental smoking status. 
      Multivariate analysis was used to confirm the association between histamine skin 
      reactivity and BMI. RESULTS: The histamine wheal size was revealed to be 
      associated with BMI (Spearman's Rho 0.161, p<0.001). This association was 
      confirmed by multivariate analysis, after adjusting for sex, age, parental 
      allergy history, parental smoking status, and allergic sensitization (coefficient 
      B 0.071, 95% confidence interval 0.030-0.112). CONCLUSIONS: Skin responses to 
      histamine were primarily correlated with increased BMI. Further studies are 
      needed to understand the clinical implication of BMI when interpreting the 
      results of skin prick test.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Kang, Ju Wan
AU  - Kang JW
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 
      South Korea.
FAU - Lee, Keun-Hwa
AU  - Lee KH
AD  - The Environmental Health Center (Atopic Dermatitis and Allergic Rhinitis), Jeju 
      National University School of Medicine, Jeju, South Korea.
FAU - Hong, Seong-Chul
AU  - Hong SC
AD  - The Environmental Health Center (Atopic Dermatitis and Allergic Rhinitis), Jeju 
      National University School of Medicine, Jeju, South Korea.
FAU - Lee, Hye-Sook
AU  - Lee HS
AD  - The Environmental Health Center (Atopic Dermatitis and Allergic Rhinitis), Jeju 
      National University School of Medicine, Jeju, South Korea.
FAU - Lee, Jaechun
AU  - Lee J
AD  - The Environmental Health Center (Atopic Dermatitis and Allergic Rhinitis), Jeju 
      National University School of Medicine, Jeju, South Korea.
FAU - Kim, Chang-Hoon
AU  - Kim CH
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 
      South Korea. Electronic address: entman@yuhs.ac.
FAU - Kim, Jeong Hong
AU  - Kim JH
AD  - The Environmental Health Center (Atopic Dermatitis and Allergic Rhinitis), Jeju 
      National University School of Medicine, Jeju, South Korea; Department of 
      Otorhinolaryngology, Jeju National University School of Medicine, Jeju, South 
      Korea. Electronic address: jeonghongkimmd@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20141118
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - *Allergens
MH  - *Asian People
MH  - *Body Mass Index
MH  - Child
MH  - Female
MH  - Histamine/*immunology
MH  - Humans
MH  - Hypersensitivity/*diagnosis/ethnology
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Multivariate Analysis
MH  - Republic of Korea
MH  - Skin Tests
OTO - NOTNLM
OT  - Allergy
OT  - Body mass index
OT  - Children
OT  - Histamine
OT  - Skin prick test
OT  - Skin reactivity
EDAT- 2014/12/17 06:00
MHDA- 2015/10/22 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/10/06 00:00 [received]
PHST- 2014/11/11 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/10/22 06:00 [medline]
AID - S0165-5876(14)00610-7 [pii]
AID - 10.1016/j.ijporl.2014.11.012 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2015 Feb;79(2):111-4. doi: 
      10.1016/j.ijporl.2014.11.012. Epub 2014 Nov 18.