PMID- 25498065
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 46
IP  - 10
DP  - 2014 Dec
TI  - HLA-identical sibling renal transplantation: influence of donor and recipient 
      gender mismatch on long-term outcomes.
PG  - 3423-5
LID - S0041-1345(14)00944-0 [pii]
LID - 10.1016/j.transproceed.2014.06.076 [doi]
AB  - BACKGROUND: Long-term function of living-related kidney allograft depends on 
      multiple variables. The aim of the present study was to assess the influence of 
      donor and recipient gender mismatch on the short and long-term outcomes in human 
      leukocyte antigen (HLA)-identical sibling renal transplants (SRTs) receiving 
      induction therapy and different immunosuppressive regimens. MATERIAL AND METHODS: 
      Twenty-nine recipients who were grafted from their HLA-identical siblings between 
      1994 and 2008 were divided into 2 groups (same and mismatched) according to 
      gender of donor and recipient. The analyzed variables were age, gender, 
      cholesterol, triglyceride, proteinuria, estimated glomerular filtration rate, 
      weight, body mass index, and serum creatinine at 6, 12, 24, 36, 48, and 60 
      months, and median follow-up. Univariate and multivariate logistic regression 
      models (when appropriate) were used to evaluate the effects of variables on 
      allograft survival. RESULTS: The number of male donors (P = .001) and recipient 
      age (P = .019) was significantly higher in the same gender group than in 
      mismatched gender group; there were no relationships between remainder analyzed 
      parameters. Multivariate regression analysis revealed that after median follow-up 
      period of 84 months (range, 60-232) the most important potential factors to 
      significantly influence long-term outcomes were male donor (P = .002), recipient 
      age (P < .001), and donor age (P = .021). CONCLUSION: Our study demonstrated that 
      male donor, and donor and recipient age affected long-term survival of 
      HLA-identical SRTs, supported with antibody induction therapy and lifetime 
      immunosuppression.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Boran, Mediha
AU  - Boran M
AD  - Department of Nephrology, Hemodialysis and Transplantation, Turkiye Higher 
      Education Hospital, Ankara, Turkey. Electronic address: drmedihaboran@yahoo.com.
FAU - Boran, Mertay
AU  - Boran M
AD  - Department of Thoracic Surgery, Duzce University School of Medicine, Duzce, 
      Turkey.
FAU - Boran, Ertay
AU  - Boran E
AD  - Department of Anesthesiology and Reanimation, Duzce University School of 
      Medicine, Duzce, Turkey.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/*epidemiology/etiology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Incidence
MH  - Kidney Transplantation/*methods
MH  - Male
MH  - Sex Factors
MH  - *Siblings
MH  - Time Factors
MH  - *Tissue Donors
MH  - *Transplant Recipients
MH  - Transplantation, Homologous
MH  - Turkey/epidemiology
EDAT- 2014/12/17 06:00
MHDA- 2015/09/15 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/02/05 00:00 [received]
PHST- 2014/05/14 00:00 [revised]
PHST- 2014/06/17 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
AID - S0041-1345(14)00944-0 [pii]
AID - 10.1016/j.transproceed.2014.06.076 [doi]
PST - ppublish
SO  - Transplant Proc. 2014 Dec;46(10):3423-5. doi: 10.1016/j.transproceed.2014.06.076.