PMID- 25498133
OWN - NLM
STAT- MEDLINE
DCOM- 20150814
LR  - 20220408
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 61
DP  - 2015 Feb
TI  - Preliminary study of anxiety symptoms, family dysfunction, and the brain-derived 
      neurotrophic factor (BDNF) Val66Met genotype in offspring of parents with bipolar 
      disorder.
PG  - 81-8
LID - S0022-3956(14)00336-7 [pii]
LID - 10.1016/j.jpsychires.2014.11.013 [doi]
AB  - Several genetic and environmental factors place youth offspring of parents with 
      bipolar disorder (BD) at high risk for developing mood and anxiety disorders. 
      Recent studies suggest that anxiety symptoms, even at subclinical levels, have 
      been associated with an increased risk for developing BD. The brain-derived 
      neurotrophic factor (BDNF) gene has been implicated in the pathophysiology of 
      both BD and anxiety disorders. We aimed to explore whether anxiety in BD 
      offspring was associated with the BDNF Val66Met polymorphism. 64 BD offspring 
      (mean age: 13.73 (S.D. 3.45) M = 30, F = 34) and 51 HC (mean age: 13.68 (S.D. 
      2.68) M = 23, F = 28) were compared on presence of the met allele and on scores 
      from the Multidimensional Anxiety Scale for Children (MASC). To assess family 
      function, we used the Family Adaptability and Cohesion Evaluation Scales 
      (FACES-IV). The Baron & Kenny method was the statistical approach used to examine 
      the moderating effects between variables. BD offspring showed higher levels of 
      overall anxiety than did the HC group. BD offspring with the val/val genotype 
      showed higher levels of anxiety than BD offspring with other genotypes. No 
      significant levels of anxiety or its association with BDNF genotype were found in 
      the HC group. BD offspring group showed significantly more family dysfunction 
      when compared with the HC group and the family dysfunction moderated the 
      association between the BDNF genotype and anxiety symptoms. This study 
      demonstrated the potential interplay of three factors: BD offspring, anxiety 
      symptoms and family dysfunction.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Park, Min-Hyeon
AU  - Park MH
AD  - Department of Psychiatry, The Catholic University of Korea, St. Vincent Hospital, 
      Suwon, Korea.
FAU - Chang, Kiki D
AU  - Chang KD
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, CA, USA.
FAU - Hallmayer, Joachim
AU  - Hallmayer J
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, CA, USA.
FAU - Howe, Meghan E
AU  - Howe ME
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, CA, USA.
FAU - Kim, Eunjoo
AU  - Kim E
AD  - Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Hong, Seung Chul
AU  - Hong SC
AD  - Department of Psychiatry, The Catholic University of Korea, St. Vincent Hospital, 
      Suwon, Korea.
FAU - Singh, Manpreet K
AU  - Singh MK
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, CA, USA. Electronic address: mksingh@stanford.edu.
LA  - eng
GR  - K23 MH064460/MH/NIMH NIH HHS/United States
GR  - K23 MH085919/MH/NIMH NIH HHS/United States
GR  - R01 MH077047/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141127
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anxiety Disorders/*genetics
MH  - Bipolar Disorder/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Child of Impaired Parents/*psychology
MH  - Family/*psychology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Parents/psychology
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Anxiety
OT  - Brain-derived neurotrophic factor
OT  - Gene-environment interaction
OT  - Pediatric bipolar
OT  - Risk
EDAT- 2014/12/17 06:00
MHDA- 2015/08/15 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/07/24 00:00 [received]
PHST- 2014/09/27 00:00 [revised]
PHST- 2014/11/20 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/08/15 06:00 [medline]
AID - S0022-3956(14)00336-7 [pii]
AID - 10.1016/j.jpsychires.2014.11.013 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2015 Feb;61:81-8. doi: 10.1016/j.jpsychires.2014.11.013. Epub 
      2014 Nov 27.