PMID- 25498245
OWN - NLM
STAT- MEDLINE
DCOM- 20151112
LR  - 20171116
IS  - 1532-2823 (Electronic)
IS  - 0952-3278 (Linking)
VI  - 94
DP  - 2015 Mar
TI  - Reduced ex vivo stimulated IL-6 response in infants randomized to fish oil from 9 
      to 18 months, especially among PPARG2 and COX2 wild types.
PG  - 21-7
LID - S0952-3278(14)00175-6 [pii]
LID - 10.1016/j.plefa.2014.10.007 [doi]
AB  - We investigated whether n-3 LCPUFA affected immune function in late infancy and 
      explored effect-modification by single nucleotide polymorphisms (SNPs) and links 
      to intestinal microbiota. Infants (n=105) were randomized to fish oil (FO, 1.2g/d 
      n-3 LCPUFA) or sunflower oil (SO)-supplements from age 9-18 months. Immune 
      function was assessed by ex vivo cytokine production in stimulated blood and 
      plasma immunoglobulin E (IgE). We genotyped functional SNPs in PPARG2 and COX2 
      and analyzed fecal microbiota by 16S-rRNA terminal restriction fragment length 
      polymorphism. FO compared to SO reduced Lactobacillus paracasei-stimulated IL-6 
      at 18 months (P=0.03, n=104). This effect was most pronounced among infants 
      wild-type for PPARG2-Pro12Ala and/or COX2-T8473C (P<0.05). Predominant bacterial 
      fragments were associated with 18 months IgE in all infants (P=0.004) (bp100) and 
      with IL-6 production among infants weaned before 9 months (P=0.047) (bp102). 
      Thus, FO reduced IL-6 in a genotype-modified manner. The microbiota was partly 
      linked to IL-6 and IgE, not directly to FO.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Harslof, Laurine B S
AU  - Harslof LB
AD  - Department of Nutrition, Exercise and Sports, Faculty of Science, University of 
      Copenhagen, Frederiksberg, Denmark.
FAU - Damsgaard, Camilla T
AU  - Damsgaard CT
AD  - Department of Nutrition, Exercise and Sports, Faculty of Science, University of 
      Copenhagen, Frederiksberg, Denmark.
FAU - Andersen, Anders D
AU  - Andersen AD
AD  - Department of Nutrition, Exercise and Sports, Faculty of Science, University of 
      Copenhagen, Frederiksberg, Denmark.
FAU - Aakjaer, Ditte L
AU  - Aakjaer DL
AD  - Department of Nutrition, Exercise and Sports, Faculty of Science, University of 
      Copenhagen, Frederiksberg, Denmark.
FAU - Michaelsen, Kim F
AU  - Michaelsen KF
AD  - Department of Nutrition, Exercise and Sports, Faculty of Science, University of 
      Copenhagen, Frederiksberg, Denmark.
FAU - Hellgren, Lars I
AU  - Hellgren LI
AD  - Department of Systems Biology, Center for Biological Sequence Analysis, Technical 
      University of Denmark, Lyngby, Denmark.
FAU - Frokiaer, Hanne
AU  - Frokiaer H
AD  - Department of Veterinary Disease Biology, Faculty of Health & Medical Sciences, 
      University of Copenhagen, Frederiksberg, Denmark.
FAU - Vogel, Ulla
AU  - Vogel U
AD  - National Research Centre for the Working Environment, Copenhagen, Denmark.
FAU - Lauritzen, Lotte
AU  - Lauritzen L
AD  - Department of Nutrition, Exercise and Sports, Faculty of Science, University of 
      Copenhagen, Frederiksberg, Denmark. Electronic address: ll@nexs.ku.dk.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20141107
PL  - Scotland
TA  - Prostaglandins Leukot Essent Fatty Acids
JT  - Prostaglandins, leukotrienes, and essential fatty acids
JID - 8802730
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fish Oils)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (PPAR gamma)
RN  - 0 (Plant Oils)
RN  - 0 (Sunflower Oil)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (PTGS2 protein, human)
SB  - IM
MH  - Bacterial Infections/immunology
MH  - Cyclooxygenase 2/*genetics
MH  - Dietary Fats, Unsaturated/administration & dosage
MH  - Feces/microbiology
MH  - Female
MH  - Fish Oils/*administration & dosage
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Interleukin-6/*metabolism
MH  - Intestines/microbiology
MH  - Male
MH  - Microbiota/drug effects
MH  - PPAR gamma/*genetics
MH  - Plant Oils/*administration & dosage
MH  - Polymorphism, Single Nucleotide
MH  - Sunflower Oil
OTO - NOTNLM
OT  - Child nutrition
OT  - Immune maturation
OT  - Long-chain n-3 polyunsaturated fatty acids
OT  - Microbiota
OT  - Polymorphisms
EDAT- 2014/12/17 06:00
MHDA- 2015/11/13 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/07/07 00:00 [received]
PHST- 2014/10/06 00:00 [revised]
PHST- 2014/10/28 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/11/13 06:00 [medline]
AID - S0952-3278(14)00175-6 [pii]
AID - 10.1016/j.plefa.2014.10.007 [doi]
PST - ppublish
SO  - Prostaglandins Leukot Essent Fatty Acids. 2015 Mar;94:21-7. doi: 
      10.1016/j.plefa.2014.10.007. Epub 2014 Nov 7.