PMID- 25498354
OWN - NLM
STAT- MEDLINE
DCOM- 20150417
LR  - 20220330
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 3
DP  - 2015 Mar
TI  - Diagnostic capability of peripapillary retinal thickness in glaucoma using 3D 
      volume scans.
PG  - 545-56.e2
LID - S0002-9394(14)00783-1 [pii]
LID - 10.1016/j.ajo.2014.12.004 [doi]
AB  - PURPOSE: To determine the diagnostic capability of spectral-domain optical 
      coherence tomography (SD OCT) peripapillary retinal thickness (RT) measurements 
      from 3-dimensional (3D) volume scans for primary open-angle glaucoma (POAG). 
      DESIGN: Cross-sectional study. METHODS: setting: Institutional. study population: 
      156 patients (89 POAG and 67 normal subjects). observation procedures: One eye of 
      each subject was included. SD OCT peripapillary RT values from 3D volume scans 
      were calculated for 4 quadrants of 3 different sized annuli. Peripapillary 
      retinal nerve fiber layer (RNFL) thickness values were also determined. main 
      outcome measures: Area under the receiver operating characteristic curve (AUROC) 
      values, sensitivity, specificity, positive and negative predictive values, and 
      positive and negative likelihood ratios. RESULTS: The top 5 RT AUROCs for all 
      glaucoma patients and for a subset of early glaucoma patients were for the 
      inferior quadrant of outer circumpapillary annulus of circular grid (OCA) 1 
      (0.959, 0.939), inferior quadrant of OCA2 (0.945, 0.921), superior quadrant of 
      OCA1 (0.890, 0.811), inferior quadrant of OCA3 (0.887, 0.854), and superior 
      quadrant of OCA2 (0.879, 0.807). Smaller RT annuli OCA1 and OCA2 consistently 
      showed better diagnostic performance than the larger RT annulus OCA3. For both 
      RNFL and RT measurements, best AUROC values were found for inferior RT OCA1 and 
      OCA2, followed by inferior and overall RNFL thickness. CONCLUSION: Peripapillary 
      RT measurements from 3D volume scans showed excellent diagnostic performance for 
      detecting both glaucoma and early glaucoma patients. Peripapillary RT values have 
      the same or better diagnostic capability compared to peripapillary RNFL thickness 
      measurements, while also having fewer algorithm errors.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Simavli, Huseyin
AU  - Simavli H
AD  - Department of Ophthalmology, Harvard Medical School, Glaucoma Service, 
      Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
FAU - Que, Christian John
AU  - Que CJ
AD  - Department of Ophthalmology, Harvard Medical School, Glaucoma Service, 
      Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
FAU - Akduman, Mustafa
AU  - Akduman M
AD  - Department of Ophthalmology, Harvard Medical School, Glaucoma Service, 
      Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
FAU - Rizzo, Jennifer L
AU  - Rizzo JL
AD  - Department of Ophthalmology, Harvard Medical School, Glaucoma Service, 
      Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
FAU - Tsikata, Edem
AU  - Tsikata E
AD  - Department of Ophthalmology, Harvard Medical School, Glaucoma Service, 
      Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
FAU - de Boer, Johannes F
AU  - de Boer JF
AD  - Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, Netherlands.
FAU - Chen, Teresa C
AU  - Chen TC
AD  - Department of Ophthalmology, Harvard Medical School, Glaucoma Service, 
      Massachusetts Eye and Ear Infirmary, Boston, Massachusetts. Electronic address: 
      teresa_chen@meei.harvard.edu.
LA  - eng
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141209
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Area Under Curve
MH  - Cross-Sectional Studies
MH  - False Positive Reactions
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Disk/*pathology
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Retina/*pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Sensitivity and Specificity
MH  - *Tomography, Optical Coherence
PMC - PMC4423415
MID - NIHMS647849
COIS- Financial Disclosures: The other authors do not have any financial conflicts of 
      interest in the design or conduct of the study.
EDAT- 2014/12/17 06:00
MHDA- 2015/04/18 06:00
PMCR- 2016/03/01
CRDT- 2014/12/16 06:00
PHST- 2014/06/09 00:00 [received]
PHST- 2014/12/01 00:00 [revised]
PHST- 2014/12/01 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/04/18 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - S0002-9394(14)00783-1 [pii]
AID - 10.1016/j.ajo.2014.12.004 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Mar;159(3):545-56.e2. doi: 10.1016/j.ajo.2014.12.004. Epub 
      2014 Dec 9.